Description
Clomipramine hydrochloride displays antidepressant and anxiolytic activity and may also be used to treat narcolepsy and obsessive-compulsive disorder (OCD). This compound inhibits serotonin transporters (SERT), norepinephrine transporters (NET), histamine receptors, muscarinic acetylcholine receptors(mAChRs), α1/2-adrenergic receptors, and 5-HT2/3/6/7 receptors. Clomipramine hydrochloride also inhibits L-type Ca2+ channels and exhibits antinociceptive activity in animal models of thermal and mechanical pain stimulation. Additionally, this compound may prolong the cardiac QT interval though its ability to decrease current amplitude from hERG K+ channels. Clomipramine also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).