• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Clonidine Hydrochloride

Clonidine Hydrochloride

Product ID C4558
Cas No. 4205-91-8
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $83.80 In stock
1 g $110.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Clonidine is an α2-adrenergic receptor agonist that also activate the imidazoline 1 receptor, increasing downstream catecholamine synthesis. Clonidine exhibits antihypertensive, neuromoduatory, cognition enhancing, antinociceptive, analgesic, and antipsychotic activities. In hypertensive rats, clonidine increases baroreceptor sensitivity and decreases blood pressure and heart rate. In other animal models, clonidine inhibits long term potentiation (synaptic plasticity) and decreases excitatory postsynaptic potentials (EPSPs) in the medial prefrontal cortex (mPFC), a potential mechanism behind clonidine’s ability to decrease glutamate release. Clonidine also improves spatial memory impairments in vivo. This compound is occasionally used clinically for its antipsychotic benefits and is most often used to treat attention deficit hyperactive disorder (ADHD) as a result of its actions that stem from binding postsynaptic α2-adrenergic receptors. In vitro, clonidine inhibits Nav1.7 Na+ channels. In vivo, clonidine decreases mechanical and thermal pain in a model of chronic constriction injury-induced neuropathy, likely due to its ability to downregulate expression of phosphorylated NMDA receptor subunit 1 (pNR1). Clonidine also displays some sedative activity and induces downstream activation of histamine H2 receptors.

Product Info

Cas No.

4205-91-8

Purity

≥98%

Formula

C9H9Cl2N3 • HCl

Formula Wt.

266.55

Chemical Name

N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine;hydrochloride

IUPAC Name

N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine;hydrochloride

Synonym

Kapvay

Melting Point

130°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C4558 MSDS PDF

Info Sheet

C4558 Info Sheet PDF

References

Li CJ, Zhou M, Li HG, et al. Clonidine suppresses the induction of long-term potentiation by inhibiting HCN channels at the schaffer collateral-CA1 synapse in anesthetized adult rats. Cell Mol Neurobiol. 2013 Nov;33(8):1075-86. PMID: 23975095.

Maruta T, Nemoto T, Satoh S, et al. Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells. J Anesth. 2011 Aug;25(4):549-57. PMID: 21607767.

Roh DH, Kim HW, Yoon SY, et al. Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain. Anesth Analg. 2008 Aug;107(2):693-700. PMID: 18633054.

Ji XH, Ji JZ, Zhang H, et al. Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. Neuropsychopharmacology. 2008 Aug;33(9):2263-71. PMID: 17957212.

Bardgett ME, Points M, Ramsey-Faulkner C, et al. The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss. Neuropsychopharmacology. 2008 Jul;33(8):1980-91. PMID: 17882233.

Ma XJ, Shen FM, Liu AJ, et al. Clonidine, moxonidine, folic acid, and mecobalamin improve baroreflex function in stroke-prone, spontaneously hypertensive rats. Acta Pharmacol Sin. 2007 Oct;28(10):1550-8. PMID: 17883939.

Li CG, Rand MJ. Rilmenidine differs from clonidine in that it lacks histamine-like activity. J Pharm Pharmacol. 1989 Jul;41(7):464-8. PMID: 2570851.

Ernsberger P, Giuliano R, Willette RN, et al. Hypotensive action of clonidine analogues correlates with binding affinity at imidazole and not alpha-2-adrenergic receptors in the rostral ventrolateral medulla. J Hypertens Suppl. 1988 Dec;6(4):S554-7. PMID: 2853758.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A491337

    9-Aminocamptothecin Hydrochloride

    Derivative of camptothecin.

    ≥98%
  • P0246

    Palomid 529

    mTOR inhibitor.

    ≥98%
  • T0109

    13-Acetyl-9-dihydrobaccatin-III

    Found in Taxus, starting material for synthesis...

    ≥98%
  • C8502

    CV-70

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • C5655

    α-Conotoxin GI

    Peptide toxin found in Conus snails; nAChR inhi...

    ≥95%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%
  • G124086

    GDC-0152 Free Base

    Promotes degradation of cIAP1

    ≥96%
  • D5994

    Doxepin Hydrochloride

    FIASMA, 5-HT1/2, M1-5 mAChR, α1-adrenergic, hi...

    ≥98%
  • V3213

    Vidarabine Monophosphate

    Nucleoside (adenosine) analog found in Tethyra ...

    ≥98.0%
  • C5600

    CO-1686

    EGFR (WT, T790M) inhibitor.

    ≥98%
  • S8012

    [Sar9]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • D3330

    Dihydrotanshinone

    Found in Salvia; fatty acid synthase and AChE i...

    ≥90%
  • P3540

    PIK-75 Hydrochloride

    p110α PI3K inhibitor.

    ≥98%
  • E6231

    (−)-Epicatechin

    Flavanol originally found in Camilla (green tea...

    ≥93%
  • L0251

    Laminin Peptide CDPGYIGSR

    Laminin-derived nonapeptide.

    ≥98%
  • I7457

    1-Isothiocyanato-6-(methylsulfinyl)-hexane

    Synthetic derivative of 6-methylsulfinyl-hexane...

    ≥98%
  • N3584

    Nivalenol

    Trichothecene mycotoxin produced by Fusarium; p...

    ≥98%
  • S680017

    SR-717 Lithium Salt

    STING agonist

    ≥98%
  • O9302

    Oxacillin Sodium Monohydrate

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • F4682

    Fluconazole

    Triazole; 14-α demethylase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only