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Colchicine

Colchicine

Product ID C5645
Cas No. 64-86-8
Purity ≥97%
Product Unit SizeCostQuantityStock
500 mg $92.00 In stock
1 g $142.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Colchicine is an anti-inflammatory anti-mitotic compound originally found in Colchicum; it is clinically used to treat gout. Colchicine binds tubulin and inhibits microtubule polymerization, inhibiting inflammasome activation, cytokine generation, and chemotaxis. Colchicine inhibits neutrophil motility. The anticancer potential of colchicine is limited by its high toxicity.

Product Info

Cas No.

64-86-8

Purity

≥97%

Formula

C22H25NO6

Formula Wt.

399.44

Chemical Name

N-[(7S)-5,6,7,9-Tetrahydro-1,10,3,10-tetramethoxy-9- oxobenzo[a]heptalen-7-yl]acetamide

IUPAC Name

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6, 7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Melting Point

142-150°C

Solubility

Soluble in water (40 mg/mL), ethanol (7 mg/ml), DMSO (14 mg/ml), or chloroform. Insoluble in petr. ether.

Appearance

Faintly yellow crystal powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C5645 MSDS PDF

Info Sheet

C5645 Info Sheet PDF

References

Dalbeth N, Lauterio TJ, Wolfe HR. Mechanism of Action of Colchicine in the Treatment of Gout. Clin Ther. 2014 Aug 21. [Epub ahead of print]. PMID: 25151572.

Ching JK, Ju JS, Pittman SK, et al. Increased autophagy accelerates colchicine-induced muscle toxicity. Autophagy. 2013 Dec;9(12):2115-25. PMID: 24184927.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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