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Cortistatin-14

Cortistatin-14

Product ID C5773
Cas No. 186901-48-4
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $174.50 In stock
1 mg $306.70 In stock
2.5 mg $579.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cortistatin-14 is an endogenous neuropeptide related to somatostatin that binds and activates somatostatin and ghrelin receptors, inhibiting secretion of growth hormone and insulin. Cortistatin-14 exhibits anticonvulsant/antiepileptic, anti-inflammatory, and antinociceptive activities. In animal models, cortistatin-14 decreases seizure duration. In macrophages, this peptide inhibits production of IL-1β. Similarly, cortistatin-14 decreases capsaicin-induced release of CGRP in rat trachea and suppresses carrageenan-induced edema in other animal models.

Product Info

Cas No.

186901-48-4

Purity

≥95%

Formula

C81H113N19O19S2

Formula Wt.

1721.02

Synonym

CST-14, Cortistatin 14 (mouse, rat)

Solubility

Soluble in water.

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C5773 MSDS PDF

Info Sheet

C5773 Info Sheet PDF

References

Aourz N, Portelli J, Coppens J, et al. Cortistatin-14 Mediates its Anticonvulsant Effects Via sst2 and sst3 but Not Ghrelin Receptors. CNS Neurosci Ther. 2014 Mar 31. [Epub ahead of print]. PMID: 24685142.

Markovics A, Szoke É, Sándor K, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. PMID: 21695504.

Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab. 2002 Aug;87(8):3783-90. PMID: 12161511.

Custom Order

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  • This field is for validation purposes and should be left unchanged.

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