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Cyclopiazonic acid is an inhibitor of sarco/endoplasmic reticulum Ca2+/ATPase (SERCA) pumps, increasing intracellular Ca2+ levels and altering contractility in smooth muscle tissues. Additionally, this compound inhibits proliferation of Plasmodium falciparum, exhibiting some potential anti-parasitic activity.
| Cas No. | 18172-33-3 |
|---|---|
| Purity | ≥98%, TLC |
| Formula | C20H20N2O3 |
| Formula Wt. | 336.39 |
| Solubility | DMSO, Methylene Chloride and Methanol. |
| Appearance | Off-white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Pulcini S, Staines HM, Pittman JK, et al. Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. J Infect Dis. 2013 Aug 1;208(3):468-78. PMID: 23599312.
Chericoni S, Testai L, Campeol E, et al. Vasodilator activity of Michelia figo Spreng. (Magnoliaceae) by in vitro functional study. J Ethnopharmacol. 2004 Apr;91(2-3):263-6. PMID: 15120449.
Darby PJ, Kwan CY, Daniel EE. Use of calcium pump inhibitors in the study of calcium regulation in smooth muscle. Biol Signals. 1993 Sep-Oct;2(5):293-304. PMID: 8038861.