LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $127.60 In stock
100 mg $317.50 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T9946

    Tylosin Phosphate

    Macrolide; peptidyl transferase inhibitor, prot...

    ≥90%
  • E7731

    17-α-Ethynylestradiol

    Synthetic steroid hormone; ER agonist.

    ≥99%
  • C0275

    Castanospermine

    O-GlcNAcase inhibitor.

    ≥98%
  • A4926

    AMG-458

    c-MET inhibitor.

    ≥98%
  • J5237

    JNJ-26854165

    MDM2 inhibitor.

    ≥98%
  • U6859

    Urocortin III, human

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • G0182

    Gastrin Releasing Peptide, pig

    Endogenous bombesin-like peptide, involved in f...

    ≥98%
  • C0254

    Candesartan Celexetil Ester

    AT1 inhibitor.

    ≥98%
  • U6858

    Urocortin II, mouse

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • U5232

    Uniconazole

    Triazole; gibberellin inhibitor, potential 14-Î...

    ≥98%
  • A5037

    Amiodarone Hydrochloride

    Voltage-gated Na+, Ca2+, K+ channel blocker, α...

    ≥98%
  • S3345

    Silymarin

    Flavonolignan mixture found in Silybum (milk th...

    ≥50% sylibin
  • T3202

    Tianeptine

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • T2835

    6-Thioguanine

    Nucleotide (guanine) analog, prevents guanine s...

    ≥90%
  • C0246

    Calcimycin

    Polyether pyrrole, divalent cation ionophore.

    ≥98%
  • C5592

    CNX-774

    BTK inhibitor.

    ≥98%
  • T2816

    L-Theanine

    Non-essential amino acid found in Camellia and ...

    ≥98%
  • T5946

    Toltrazuril

    Coccidiostat; mitochondrial respiration inhibit...

    ≥98%
  • M4102

    MK-1775

    Wee1 inhibitor.

    ≥98%
  • D3208

    Diclazuril

    Coccidiostat, GAPDH inhibitor.

    ≥98%