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Cytochalasin B

Cytochalasin B

Product ID C9879
Cas No. 14930-96-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.20 In stock
5 mg $273.60 In stock
Bulk Quote

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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Custom Order

Description

Cytochalasin B is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin B inhibits secretion of corticosterone and aldosterone from the adrenal gland in vivo. In fibroblasts, cytochalasin B inhibits FGF- and PDGF-induced mitogenesis. Additionally, this compound’s disruption of actin polymerization prevents phagocytosis in macrophages.

Product Info

Cas No.

14930-96-2

Purity

≥98%

Formula

C29H37NO5

Formula Wt.

479.61

IUPAC Name

(1S,4E,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicosa-4,12-diene-3,21-dione

Melting Point

221-223°C

Solubility

DMSO or Ethanol

Appearance

White Crystalline Solid

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C9879 MSDS PDF

Info Sheet

C9879 Info Sheet PDF

References

Delarue C, Esneu M, Fournier A, et al. Role of the cytoskeleton in the secretory response of the frog adrenal gland to calcitonin gene-related peptide. J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):21-7. PMID: 9449202.

Reist RH, Dey RD, Durham JP, et al. Inhibition of proliferative activity of pulmonary fibroblasts by tetrandrine. Toxicol Appl Pharmacol. 1993 Sep;122(1):70-6. PMID: 8104360.

Painter RG, Whisenand J, McIntosh AT. Effects of cytochalasin B on actin and myosin association with particle binding sites in mouse macrophages: implications with regard to the mechanism of action of the cytochalasins. J Cell Biol. 1981 Nov;91(2 Pt 1):373-84. PMID: 7198123.

Custom Order

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