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Dapoxetine Hydrochloride

Dapoxetine Hydrochloride

Product ID D0263
Cas No. 129938-20-1
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $71.50 In stock
50 mg $245.30 In stock
100 mg $408.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dapoxetine hydrochloride was initially designed as an antidepressant but was found more beneficial in the treatment of premature ejaculation due to its lack of significant effects on mood and quick adsorption and elimination kinetics. Dapoxetine is a centrally-acting SSRI that modulates serotonin levels in relevant areas such as the lateral paragigantocellular nucleus through inhibition of the serotonin transporter (SERT). This compound also decreases peak amplitude and accelerates the decay rate of current inactivation in a variety of voltage-gated K+ channels.

Product Info

Cas No.

129938-20-1

Purity

≥99%

Formula

C21H23NO • HCl

Formula Wt.

341.87

IUPAC Name

(1S)-N, N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine;hydrochloride

Melting Point

180-182°C

Solubility

Soluble in DMSO (68 mg/ml at 25° C), chloroform, methanol, water (68 mg/ml at 25° C), and ethanol (68 mg/ml at 25° C).

Appearance

Off-White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D0263 MSDS PDF

Info Sheet

D0263 Info Sheet PDF

References

McMahon CG. Dapoxetine: a new option in the medical management of premature ejaculation. Ther Adv Urol. 2012 Oct;4(5):233-51. PMID: 23024705.

Jeong I, Yoon SH, Hahn SJ. Effects of dapoxetine on cloned Kv1.5 channels expressed in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul;385(7):707-16. PMID: 22568341.

Jeong I, Kim SW, Yoon SH, et al. Block of cloned Kv4.3 potassium channels by dapoxetine. Neuropharmacology. 2012 Jun;62(7):2261-6. PMID: 22192593.

Clément P, Bernabé J, Gengo P, et al. Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine. Eur Urol. 2007 Mar;51(3):825-32. PMID: 17064843.

Custom Order

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