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DAPT is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective and anticancer activities. DAPT inhibits proliferation of cancer stem cells. It also promotes differentiation of neural stem cells into neurons with Lingo-1 shRNA as a possible treatment for spinal cord injury.
| Cas No. | 208255-80-5 |
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| Purity | ≥98% |
| Formula | C23H26F2N2O4 |
| Formula Wt. | 432.47 |
| IUPAC Name | 2-Methyl-2-propanyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate |
| Synonym | GSI-IX |
| Solubility | DMSO: ≥ 215 mg/mL |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Liu J, Mao Z, Huang J, et al. Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy. Biochem Biophys Res Commun. 2014 Feb 21;444(4):670-5. PMID: 24502949.
Wang J., Ye Z., et al. Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons. Brain Res. 1634:34-44 (2016). PMID: 26607252.