• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Demeclocycline Hydrochloride

Demeclocycline Hydrochloride

Product ID D1748
Cas No. 64-73-3
Purity ≥85%
Product Unit SizeCostQuantityStock
100 mg $69.10 In stock
250 mg $103.30 In stock
1 g $198.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Demeclocycline is a tetracycline antibiotic found in Streptomyces. Like other tetracyclines, demeclocycline exhibits antibacterial efficacy by binding the 30S bacterial ribosomal subunit and inhibiting aminoacyl tRNA binding, therefore preventing protein translation and synthesis. Demeclocycline decreases expression of aquaporin 2 (AQP2) and adenylate cyclase 5/6, decreasing cAMP levels and preventing hyponatremia in SIADH. Demeclocycline also exhibits neuroprotective activity in cellular models of glutamate-induced neuronal death and in animal models of cerebral ischemia, potentially through the inhibition of calpain.

Product Info

Cas No.

64-73-3

Purity

≥85%

Formula

C21H21ClN2O8 • HCl

Formula Wt.

501.30

Chemical Name

[4S-(4α,4aα,5aα,6β,12aα)]-7-Chloro-4-(dimethyl- amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a- pentahydroxy-1,11,-dioxo-2-naphthacenecarboxamide hydrochloride

IUPAC Name

(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11, 12a-pentahydroxy-3,12-dioxo-4a,5,5a, 6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride

Synonym

Clortetrin, Demetraciclina, Detravis, Mexocine

Solubility

Soluble in water (16 mg/mL), methanol (20 mg/mL).

Appearance

Yellow Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D1748 MSDS PDF

Info Sheet

D1748 Info Sheet PDF

References

Kortenoeven ML, Sinke AP, Hadrup N, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. PMID: 24154696.

Jiang SX, Lertvorachon J, Hou ST, et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem. 2005 Oct 7;280(40):33811-8. PMID: 16091365.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V1870

    Verruculogen

    Mycotoxin produced by Aspergillus; BK K+ channe...

    ≥95%
  • T5672

    Tosufloxacin Tosylate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • E4417

    Eledoisin Related Peptide

    Peptide, substance P analog; NK agonist.

    ≥95%
  • A5278

    Angiotensin III, human

    Endogenous peptide, cleavage product of AT II; ...

    ≥95%
  • B1655

    S-(N-Benzylthiocarbamoyl)-L-cysteine

    Cysteine conjugate of benzyl isothiocyanate (BI...

    ≥98%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • M017545

    Manumycin A

    Natural antibiotic found in Streptomyces parvul...

    ≥98%
  • T3039

    Thienyloctyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • S3346

    Silodosin

    α1A-adrenergic antagonist.

    ≥98%
  • V9228

    VX-765

    NLRP3 and caspase-1 inhibitor.

    ≥98%
  • D1776

    Desmopressin

    Synthetic vasopressin derivative; V2R agonist.<...

    ≥95%
  • D6957

    Droloxifene

    Triphenylthylene, tamoxifen analog; SERM.

    ≥98%
  • P2502

    Phenethyl Glucosinolate Potassium

    Found in cruciferous vegetables.

    ≥97%
  • B0026

    Bafilomycin B1

    Macrolide; vacuolar H+-ATPase inhibitor.

    ≥97%
  • R5745

    Rolipram

    Anxiolytic-like agent that stimulates angiogene...

    ≥98%
  • N3474

    Nisoldipine

    Calcium channel blocker.

    ≥98%
  • A1370

    Adrenomedullin (22-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • S6247

    Splitomicin

    SIRT1/2 inhibitor.

    ≥98%
  • M3379

    Mitoxantrone Dihydrochloride

    Anthracenedione, DNA intercalator; Pim-1 inhibi...

    ≥98%
  • A2400

    AG-1024

    Tyrphostin; IGF-1R inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only