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Aminopterin

Product ID A5001
Cas No. 54-62-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $75.00 In stock
25 mg $200.00 In stock
100 mg $550.00 In stock
500 mg $1,250.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Aminopterin is a folic acid analog and derivative of pterin; it is very similar to methotrexate in structure. Aminopterin exhibits anticancer chemotherapeutic and immunosuppressive activities. Like other folic acid analogs, aminopterin inhibits dihydrofolate reductase, depleting nucleotide pools and inhibiting synthesis of DNA and RNA. Aminopterin was one of the first compounds to successfully induce remission in childhood leukemia and was clinically used to treat rheumatoid arthritis, but has since been replaced by methotrexate.

Product Info

Cas No.

54-62-6

Purity

≥98%

Formula

C19H20N8O5

Formula Wt.

440.41

Chemical Name

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

IUPAC Name

2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

Synonym

4-Aminofolic acid

Melting Point

230-235°C (dec)

Solubility

Soluble in DMSO or 2 N NaOH (50mg/mL).

Appearance

Dark Yellow-Brown Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5001 MSDS PDF

Info Sheet

A5001 Info Sheet PDF

References

Visentin M, Zhao R, Goldman ID. The antifolates. Hematol Oncol Clin North Am. 2012 Jun;26(3):629-48. PMID: 22520983.

McGuire JJ. Anticancer antifolates: current status and future directions. Curr Pharm Des. 2003;9(31):2593-613. PMID: 14529544.

Baggott JE, Morgan SL, Ha TS, et al. Antifolates in rheumatoid arthritis: a hypothetical mechanism of action. Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8:S101-5. PMID: 8324932.

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