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This synthetic peptide analog of dermorphin activates μ-opioid receptors (μORs) and δ-opioid receptors (δORs). Like other similar opioid agonists, this peptide affects learning and memory as well as motor activity and exhibits neuromodulatory and antinociceptive/analgesic activities.
| Purity | ≥95% |
|---|---|
| Formula | C44H59N11O10 |
| Formula Wt. | 902.03 |
| Solubility | Soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Vonhof S, Barone FC, Price WJ, et al. Receptor binding and biological activity of the dermorphin analog Tyr-D-Arg(2)-Phe-Sar (TAPS). Eur J Pharmacol. 2001 Mar 23;416(1-2):83-93. PMID: 11282116.
Ukai M, Kobayashi T, Mori K, et al. Attenuation of memory with Tyr-D-Arg-Phe-beta-Ala-NH2, a novel dermorphin analog with high affinity for mu-opioid receptors. Eur J Pharmacol. 1995 Dec 20;287(3):245-9. PMID: 8991797.
Paakkari P, Paakkari I, Vonhof S, et al. Dermorphin analog Tyr-D-Arg2-Phe-sarcosine-induced opioid analgesia and respiratory stimulation: the role of mu 1-receptors? J Pharmacol Exp Ther. 1993 Aug;266(2):544-50. PMID: 8394909.