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Dexrazoxane Hydrochloride

Dexrazoxane Hydrochloride

Product ID D1995
Cas No. 149003-01-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $78.80 In stock
25 mg $225.80 In stock
100 mg $614.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dexrazoxane is an iron chelator that exhibits cardioprotective, antioxidative, pro-angiogenic, and anti-parasitic activities. Dexrazoxane decreases superoxide formation and prevents anthracycline-induced cardiotoxicity. In animal models of myocardial infarction, dexrazoxane decreases infarct size, increases capillary density, and improves cardiac function. Additionally, this compound displays antimalarial benefit, inhibiting growth of Plasmodium.

Product Info

Cas No.

149003-01-0

Purity

≥98%

Formula

C11H16N4O4 • HCl

Formula Wt.

304.73

IUPAC Name

4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;hydrochloride

Melting Point

191-197°C

Solubility

Sparingly soluble in water and 0.1 N HCl, slightly soluble in ethanol and methanol, and practically insoluble in nonpolar organic solvents.

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D1995 MSDS PDF

Info Sheet

D1995 Info Sheet PDF

References

Doroshow JH. Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics. Curr Pharm Biotechnol. 2012 Aug;13(10):1949-56. PMID: 22352729.

Zhou L, Sung RY, Li K, et al. Cardioprotective effect of dexrazoxane in a rat model of myocardial infarction: anti-apoptosis and promoting angiogenesis. Int J Cardiol. 2011 Oct 20;152(2):196-201. PMID: 20692056.

Jones RL. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7. PMID: 19018683.

Loyevsky M, Sacci JB Jr, Boehme P, et al. Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol. 1999 Feb;91(2):105-14. PMID: 9990337.

Custom Order

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