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Diclazuril is an anti-parasitic compound that is commercially used in poultry and livestock feed. Diclazuril acts as a coccidiostat. In vivo, diclazuril protects against Toxoplasma infection and induces apoptosis in Eimeria by inhibiting activity of GAPDH.
| Cas No. | 101831-37-2 |
|---|---|
| Purity | ≥98% |
| Formula | C17H10Cl2N4O2 |
| Formula Wt. | 407.64 |
| Chemical Name | 2,6-Dichloro-a-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile |
| IUPAC Name | 2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2, 4-triazin-2-yl)phenyl]acetonitrile |
| Synonym | R-64433, Clinacox |
| Melting Point | 290.5°C |
| Solubility | Insoluble in water. Slightly soluble in DMSO, THF. |
| Appearance | Off-White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Oz HS, Tobin T. Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis. Int J Clin Med. 2014 Jan 1;5(3):93-101. PMID: 24851194.
Wang C, Han C, Li T, et al. Nuclear translocation and accumulation of glyceraldehyde-3-phosphate dehydrogenase involved in diclazuril-induced apoptosis in Eimeria tenella (E. tenella). Vet Res. 2013 May 7;44:29. PMID: 23651214.