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Diminazene Aceturate

Diminazene Aceturate

Product ID D3353
Cas No. 908-54-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $81.70 In stock
5 g $291.60 In stock
25 g $716.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Diminazene is a diamidine compound that activates angiotensin-converting enzyme 2 (ACE2), opposing the effects of angiotensin II (AT II) and the AT1 receptor. Diminazene acts as an antibacterial and anti-parasitic compound, inhibiting DNA polymerase in eukaryotic cells. Diminazene exhibits efficacy against Trypanosoma, Babesia, Brucella, and Streptococcus.

Product Info

Cas No.

908-54-3

Purity

≥98%

Formula

C14H15N7 • 2C4H7NO3

Formula Wt.

515.52

Chemical Name

Glycine, N-acetyl-, compd. with 4,4'-(1-triazene-1,3- diyl)bis(benzenecarboximidamide) (2:1)

IUPAC Name

2-acetamidoacetic acid;4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide

Synonym

Azidin, Ganasag, Berenil, Beronal, Bevenil.

Melting Point

217°C (dec)

Solubility

Soluble in 14 parts water (20oC). Slightly soluble in alcohol.

Appearance

Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3353 MSDS PDF

Info Sheet

D3353 Info Sheet PDF

References

Mecca AP, Regenhardt RW, O'Connor TE, et al. Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Exp Physiol. 2011 Oct;96(10):1084-96. doi: 10.1113/expphysiol.2011.058578. Epub 2011 Jun 17. PMID: 21685445.

Peregrine AS, Mamman M. Pharmacology of diminazene: a review. Acta Trop. 1993 Sep;54(3-4):185-203. PMID: 7902657.

Marcus SL, Kopelman R, Koll B, et al. Effects of exogenous polyamine and trypanocides on the DNA polymerase activities from Trypanosoma brucei brucei, mouse thymus and murine leukemia virus. Mol Biochem Parasitol. 1982 Apr;5(4):231-43. PMID: 6178972.

Shenov V, Gjymishka A, Jarajapu YP, et al. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. Am J Respir Crit Care Med. 2013 Mar 15;187(6):648-657. PMID: 23370913.

Custom Order

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