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Diminazene is a diamidine compound that activates angiotensin-converting enzyme 2 (ACE2), opposing the effects of angiotensin II (AT II) and the AT1 receptor. Diminazene acts as an antibacterial and anti-parasitic compound, inhibiting DNA polymerase in eukaryotic cells. Diminazene exhibits efficacy against Trypanosoma, Babesia, Brucella, and Streptococcus.
| Cas No. | 908-54-3 |
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| Purity | ≥98% |
| Formula | C14H15N7 • 2C4H7NO3 |
| Formula Wt. | 515.52 |
| Chemical Name | Glycine, N-acetyl-, compd. with 4,4'-(1-triazene-1,3- diyl)bis(benzenecarboximidamide) (2:1) |
| IUPAC Name | 2-acetamidoacetic acid;4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide |
| Synonym | Azidin, Ganasag, Berenil, Beronal, Bevenil. |
| Melting Point | 217°C (dec) |
| Solubility | Soluble in 14 parts water (20oC). Slightly soluble in alcohol. |
| Appearance | Yellow Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Mecca AP, Regenhardt RW, O'Connor TE, et al. Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Exp Physiol. 2011 Oct;96(10):1084-96. doi: 10.1113/expphysiol.2011.058578. Epub 2011 Jun 17. PMID: 21685445.
Peregrine AS, Mamman M. Pharmacology of diminazene: a review. Acta Trop. 1993 Sep;54(3-4):185-203. PMID: 7902657.
Marcus SL, Kopelman R, Koll B, et al. Effects of exogenous polyamine and trypanocides on the DNA polymerase activities from Trypanosoma brucei brucei, mouse thymus and murine leukemia virus. Mol Biochem Parasitol. 1982 Apr;5(4):231-43. PMID: 6178972.
Shenov V, Gjymishka A, Jarajapu YP, et al. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. Am J Respir Crit Care Med. 2013 Mar 15;187(6):648-657. PMID: 23370913.