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EPZ-5676

EPZ-5676

Product ID E6398
Cas No. 1380288-87-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $173.50 In stock
5 mg $300.60 In stock
10 mg $470.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

EPZ-5676 is an inhibitor of DOT1L histone methyltransferase (HMT) that exhibits anticancer chemotherapeutic activity. In acute myelogenous leukemia (AML) cells with MLL gene translocations, EPZ-5676 displays cytotoxicity; in similar animal models, this compound induces tumor regression without toxicity.

Product Info

Cas No.

1380288-87-8

Purity

≥98%

Formula

C30H42N8O3

Formula Wt.

562.71

IUPAC Name

(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol

Synonym

EPZ5676, Pinometostat

Solubility

DMSO 100 mg/mL warmed (177.71 mM) Ethanol 92 mg/mL warmed (163.49 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

E6398 MSDS PDF

Info Sheet

E6398 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Basavapathruni A, Olhava EJ, Daigle SR, et al. Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor. Biopharm Drug Dispos. 2014 Jan 10. [Epub ahead of print]. PMID: 24415392.

Daigle SR, Olhava EJ, Therkelsen CA, et al. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood. 2013 Aug 8;122(6):1017-25. PMID: 23801631.

Custom Order

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