Description
Etidronate is a bisphosphonate and chelating agent that exhibits anti-osteoporotic, anti-resorptive, and anti-inflammatory activities. Etidronate is clinically used to treat osteoporosis, inhibiting bone calcification and resorption. Etidronate is also commercially used to prevent Ca2+ and mineral deposition. In macrophages, etidronate inhibits production of COX-2 and prostaglandin E2 (PGE2) and decreases levels of IL-6, TNF-α, and IL-1β.