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Etidronate Disodium

Etidronate Disodium

Product ID E7433
Cas No. 7414-83-7
Purity ≥98%
Product Unit SizeCostQuantityStock
250mg $97.70 In stock
1 g $135.10 In stock
5 g $443.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Etidronate is a bisphosphonate and chelating agent that exhibits anti-osteoporotic, anti-resorptive, and anti-inflammatory activities. Etidronate is clinically used to treat osteoporosis, inhibiting bone calcification and resorption. Etidronate is also commercially used to prevent Ca2+ and mineral deposition. In macrophages, etidronate inhibits production of COX-2 and prostaglandin E2 (PGE2) and decreases levels of IL-6, TNF-α, and IL-1β.

Product Info

Cas No.

7414-83-7

Purity

≥98%

Formula

C2H6Na2O7P2

Formula Wt.

249.99

Chemical Name

(1-Hydroxyethylidene)bisphosphonic acid disodium salt

IUPAC Name

disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl] phosphinate

Synonym

Disodium dihydrogen (1-hydroxyethylidene)bis- [phosphate], Didronel, Diphos, Etidron

Melting Point

>300°C

Solubility

Soluble in water (>26mg/mL).

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7433 MSDS PDF

Info Sheet

E7433 Info Sheet PDF

References

Asano S, Suzuki A, Itoh M. Etidronate for treatment of osteoporosis. Nihon Rinsho. 2009 May;67(5):938-42. PMID: 19432113.

Lomashvili KA, Monier-Faugere MC, Wang X, et al. Effect of bisphosphonates on vascular calcification and bone metabolism in experimental renal failure. Kidney Int. 2009 Mar;75(6):617-25. PMID: 19129793.

Suzuki Y, Nishiyama T, Hasuda K, et al. Effect of etidronate on COX-2 expression and PGE(2) production in macrophage-like RAW 264.7 cells stimulated by titanium particles. J Orthop Sci. 2007 Nov;12(6):568-77. PMID: 18040640.

Custom Order

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