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Ferulic Acid

Ferulic Acid

Product ID F1669
Cas No. 1135-24-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $48.10 In stock
25 g $78.10 In stock
100 g $237.90 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ferulic acid is a metabolite of verbascoside and a hydroxycinnamic acid found in various plant sources that displays neuroprotective, antioxidative, anti-inflammatory, antidepressant, and antinociceptive activities. Ferulic acid decreases oxidative stress and inflammation, exhibiting therapeutic and protective effects in animal models of diabetic nephropathy. Ferulic acid protects against oxidative damage in cellular models by decreasing levels of IL-1β and TNF-α and increasing levels of superoxide dismutase and glutathione. In animal models, this compound acts as an antinociceptive and antidepressant, decreasing levels of NE, DA, 5-HT, substance P, p65, and NF-κB in the hippocampus and frontal cortex. Ferulic acid displays potential benefit in the treatment of Alzheimer’s disease as well, as it reverses morphological effects induced by amyloid-β (Aβ) dimers in Paracentrotus lividus embryos. Additionally, ferulic acid inhibits presynaptic glutamate release from cortical synaptosomes in rats through chelation of extracellular Ca2+ ions.

Product Info

Cas No.

1135-24-6

Purity

≥98%

Formula

C10H10O4

Formula Wt.

194.18

Chemical Name

3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid

IUPAC Name

(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid

Synonym

Caffeic acid 3-methyl ether, 4-Hydroxy-3-methoxy- cinnamic acid

Melting Point

168-175°C

Solubility

Soluble in hot water, or ethyl acetate. DMSO: 39 mg/mL, Ethanol: 39 mg/mL

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F1669 MSDS PDF

Info Sheet

F1669 Info Sheet PDF

References

Quirantes-Piné R, Herranz-López M, Funes L, et al. Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats. Phytomedicine. 2013 Sep 15;20(12):1112-8. PMID: 23827667.

Xu Y, Zhang L, Shao T, et al. Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses. Metab Brain Dis. 2013 Dec;28(4):571-83. PMID: 23584961.

Picone P, Nuzzo D, Di Carlo M. Ferulic acid: a natural antioxidant against oxidative stress induced by oligomeric A-beta on sea urchin embryo. Biol Bull. 2013 Feb;224(1):18-28. PMID: 23493505.

Lin TY, Lu CW, Huang SK, et al. Ferulic acid suppresses glutamate release through inhibition of voltage-dependent calcium entry in rat cerebrocortical nerve terminals. J Med Food. 2013 Feb;16(2):112-9. PMID: 23342970.

Choi R, Kim BH, Naowaboot J, et al. Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes. Exp Mol Med. 2011 Dec 31;43(12):676-83. PMID: 21975281.

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