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Wortmannin

Wortmannin

Product ID W5769
Cas No. 19545-26-7
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $83.00 In stock
5 mg $324.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Wortmannin is a steroid metabolite initially produced by fungi in the Penicillum genus. Wortmannin inhibits PI3K, mTOR, DNA-PK, PI4K, MLCK, MAPKs, and polo-like kinases (PLKs). In vivo, wortmannin inhibits activation of Akt and AMPK and decreases translocation of GLUT4, suppressing glucose uptake. Wortmannin also inhibits insulin-induced skeletal myoblast differentiation.

Product Info

Cas No.

19545-26-7

Purity

≥97%

Formula

C23H24O8

Formula Wt.

428.43

Chemical Name

(1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,-11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]ideno[4,5-h]-2-benzopyran-3,6,9- trione

IUPAC Name

[(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate

Synonym

Wartmannin, KY 12420, SL-2052

Melting Point

240°C

Solubility

Soluble in methanol and DMSO.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

W5769 MSDS PDF

Info Sheet

W5769 Info Sheet PDF

References

Zhou X, Zhao Y, Xu L, et al. Wortmannin and U0126 inhibit the promoting effect of insulin on differentiation of skeletal myoblasts in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jul;30(7):717-20. PMID: 25001936.

Ji L, Zhang X, Liu W, et al. AMPK-regulated and Akt-dependent enhancement of glucose uptake is essential in ischemic preconditioning-alleviated reperfusion injury. PLoS One. 2013 Jul 26;8(7):e69910. PMID: 23922853.

Zaika O, Lara LS, Gamper N, et al. Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels. J Physiol. 2006 Aug 15;575(Pt 1):49-67. PMID: 16777936.

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