Description
Flavokawain B is a chalcone kavalactone originally found in Piper methysticum (kava plant). Flavokawain B exhibits hepatotoxic and anti-inflammatory activities. This compound inhibits degradation of IκBα and activation of NF-κB.
Flavokawain B
Product ID F4503
Cas No. 1775-97-9
Purity ≥97%
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Product Info
| Cas No. | 1775-97-9 |
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| Purity | ≥97% |
| Formula | C17H16O4 |
| Formula Wt. | 284.31 |
| IUPAC Name | (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one |
| Melting Point | 85-87°C |
| Solubility | DMSO to 35 mM. Insoluble in water. Soluble in methanol. |
| Appearance | Orange/Yellow crystalline powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Teschke R, Qiu SX, Lebot V. Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. Dig Liver Dis. 2011 Sep;43(9):676-81. PMID: 21377431.
Folmer F, Blasius R, Morceau F, et al. Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives. Biochem Pharmacol. 2006 Apr 14;71(8):1206-18. PMID: 16464438.
Sakai T, Eskander RN, Guo Y, et al. Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. J Orthop Res. 2012 Jul;30(7):1045-1050. PMID: 22213202.