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FLI-06 is a dihydropyridine inhibitor of γ-secretase that suppresses Notch signaling in vitro and in vivo. FLI-06 inhibits protein secretion prior to endoplasmic reticulum exit. Like other Notch signaling inhibitors, FLI-06 likely displays neuroprotective activity.
| Cas No. | 313967-18-9 |
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| Purity | ≥99% |
| Formula | C25H30N2O5 |
| Formula Wt. | 438.52 |
| Chemical Name | 1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester |
| IUPAC Name | Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate |
| Synonym | FLI 06, FLI06 |
| Solubility | DMSO 88 mg/mL (200.67 mM) Ethanol 8 mg/mL (18.24 mM) Water Insoluble |
| Appearance | Yellow crystal powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Krämer A, Mentrup T, Kleizen B, et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol. 2013 Nov;9(11):731-8. PMID: 24077179.