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Floxuridine is a fluorinated pyrimidine; it is an analog of 5-fluorouracil (5-FU). Floxuridine exhibits antiviral and anticancer chemotherapeutic activities. Floxuridine acts as an antimetabolite, inhibiting thymidylate synthase and inducing apoptosis in cancer cells. This compound also inhibits replication of dengue virus.
| Cas No. | 50-91-9 |
|---|---|
| Purity | ≥98% |
| Formula | C9H11FN2O5 |
| Formula Wt. | 246.19 |
| Chemical Name | 2'-Deoxy-5-fluorouridine |
| IUPAC Name | 5-fluoro-1-[(2R,4S, 5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| Synonym | NSC-27640, FUDR |
| Melting Point | 150-151°C |
| Solubility | Soluble in water. |
| Appearance | White Crystalline |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Fischer MA, Smith JL, Shum D, et al. Flaviviruses are sensitive to inhibition of thymidine synthesis pathways. J Virol. 2013 Sep;87(17):9411-9. PMID: 23824813.
Muñoz-Pinedo C, Robledo G, López-Rivas A. Thymidylate synthase inhibition triggers glucose-dependent apoptosis in p53-negative leukemic cells. FEBS Lett. 2004 Jul 16;570(1-3):205-10. PMID: 15251465.
Tobias SC, Borch RF. Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs. J Med Chem. 2001 Dec 6;44(25):4475-80. PMID: 11728193.