• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Flupirtine Maleate

Flupirtine Maleate

Product ID F4583
Cas No. 75507-68-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $120.60 In stock
25 mg $251.50 In stock
100 mg $804.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Flupirtine maleate is an agonist at voltage-gated KCNQ/Kv7 K+ channels; opening of these channels on neurons facilitates M-current generation and decreases axonal excitability. In addition to its modulation of K+ channels, flupirtine maleate also inhibits NMDA receptors and shifts gating of GABA-A receptors to decrease circulating GABA concentrations. Flupirtine maleate is an effective non-sedative analgesic, showing benefit in clinical trials of neurosurgical patients. In animal models, this compound also attenuates development of and reverses established pulmonary arterial hypertension, suggesting antihypertensive activity.

Product Info

Cas No.

75507-68-5

Purity

≥98%

Formula

C15H17FN4O2 • C4H4O4

Formula Wt.

304.32

IUPAC Name

(Z)-but-2-enedioic acid;ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate

Melting Point

174-175℃

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F4583 MSDS PDF

Info Sheet

F4583 Info Sheet PDF

References

Yadav G, Choupoo S, Das SK, et al. Evaluating the Role of Flupirtine for Postcraniotomy Pain and Compare it With Diclofenac Sodium: A Prospective, Randomized, Double Blind, Placebo-controlled Study. J Neurosurg Anesthesiol. 2013 Jun 11. [Epub ahead of print]. PMID: 23764718.

Fleckenstein J, Sittl R, Averbeck B, et al. Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial. J Transl Med. 2013 Feb 8;11:34. PMID: 23394517.

Klinger F, Geier P, Dorostkar MM, et al. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol. 2012 Jul;166(5):1631-42. PMID: 22188423.

Harish S, Bhuvana K, Bengalorkar GM, et al. Flupirtine: Clinical pharmacology. J Anaesthesiol Clin Pharmacol. 2012 Apr;28(2):172-7. PMID: 22557738.

Devulder J. Flupirtine in pain management: pharmacological properties and clinical use. CNS Drugs. 2010 Oct;24(10):867-81. PMID: 20839897.

Morecroft I, Murray A, Nilsen M, et al. Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. Br J Pharmacol. 2009 Aug;157(7):1241-9. PMID: 19508393.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A1318

    Adenine

    Endogenous purine nucleotide base, required for...

    ≥98%
  • B1898

    Bezafibrate

    Fibrate; PPARα agonist.

    ≥98%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • A0922

    Acetyl-L-Carnitine Hydrochloride

    Carnitine derivative, involved in energy homeos...

    ≥98%
  • F5770

    Formononetin

    Isoflavone found in legumes such as soy.

    ≥90%
  • M177521

    Menaquinone-7

    2-methyl-1,4-naphthoquinone derivative

    98%
  • E2542

    Met-Enkephalin Amide

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%
  • H9815

    25-Hydroxyvitamin D3

    Vitamin D, calcitriol prodrug; VDR agonist.

    ≥98%
  • R5773

    Rosiglitazone

    Thiazolidinedione; PPARγ agonist.

    ≥99%
  • F1650

    Fenbendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • B011458

    Baloxavir

    Cap-dependent endonuclease inhibitor

    ≥ 99%
  • I0901

    Icariin

    Flavonol glycoside originally found in Epimediu...

    ≥97%
  • A601022

    Apararenone

    Non-steroidal MRA

    ≥98%
  • C0262

    L-Carnitine

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • Y0052

    Yangonin

    Dienolide kavalactone originally found in Piper...

    ≥98%
  • C1867

    Ceramide

    Endogenous sphingosine-based lipid, component o...

    ≥98%
  • B8276

    Butyric Acid Sodium

    HDAC inhibitor, RNA splicing modulator.

    ≥98%
  • P2100

    PF-06447475

    LRRK2 inhibitor.

    ≥98%
  • E6256

    Epothilone A

    Microtubule depolymerization inhibitor.

    ≥95%
  • D1777

    Desmopressin Acetate

    Synthetic peptide, vasopressin derivative; V2 a...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only