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Fluvastatin Sodium

Fluvastatin Sodium

Product ID F4482
Cas No. 93957-55-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $50.90 In stock
50 mg $153.10 In stock
100 mg $245.30 In stock
Bulk Quote

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  • Description
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Description

Fluvastatin is an inhibitor of HMG-CoA reductase that is clinically used to lower cholesterol and treat cardiovascular disease. Fluvastatin exhibits anti-hyperlipidemic, anti-fibrotic, cardioprotective, antiviral, antithrombotic, antioxidative, vasorelaxant, anti-atherosclerotic, and anticancer activities. Fluvastatin suppresses viral load of hepatitis C virus in a clinical setting and prevents viral replication. In vitro, fluvastatin decreases platelet activation by increasing PECAM-1 signaling and inhibiting activation of Akt. Additionally, fluvastatin scavenges hydroxyl radicals in vitro. In other cellular models, fluvastatin increases expression of NO and phospholipase 2 (PLA2) and decreases levels of angiotensin II (AT II) and ROCK. Additionally, this compound induces apoptosis and G2/M phase cell cycle arrest, decreases the mitochondrial membrane potential, and increases release of cytochrome c and activation of caspase 3 in hepatocellular carcinoma cells. In animal models of cardiac distress, fluvastatin improves left ventricular function and prevent fibrosis by inhibiting RhoA and decreasing levels of CTFG and fibronectin.

Product Info

Cas No.

93957-55-2

Purity

≥98%

Formula

C24H25FNNaO4

Formula Wt.

433.45

Chemical Name

(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methyl- ethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt

IUPAC Name

sodium;(6E,3R*,5S*)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3, 5-dihydroxyhept-6-enoate

Synonym

Fluindostatin, XU-62-320, Lescol, Lipaxan, Primexin

Melting Point

194-197°C

Solubility

Soluble in water (50 mM), methanol, ethanol, and DMSO (100 mM)

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F4482 MSDS PDF

Info Sheet

F4482 Info Sheet PDF

Brochures

Statins Flyer

References

Wuestenberg A, Kah J, Singethan K, et al. Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin. PLoS One. 2014 May 6;9(5):e96533. PMID: 24801208.

Moraes LA, Vaiyapuri S, Sasikumar P, et al. Antithrombotic actions of statins involve PECAM-1 signaling. Blood. 2013 Oct 31;122(18):3188-96. PMID: 24030383.

Vandjelovic N, Zhu H, Misra HP, et al. EPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin. Mol Cell Biochem. 2012 May;364(1-2):71-7. PMID: 22207075.

Yaktubay Döndaş N, Sucu N, Coşkun Yilmaz B, et al. Molecular mechanism of vasorelaxant and antiatherogenic effects of the statins in the human saphenous vein graft. Eur J Pharmacol. 2011 Sep;666(1-3):150-7. PMID: 21620829.

Dai QM, Lu J, Liu NF. Fluvastatin attenuates myocardial interstitial fibrosis and cardiac dysfunction in diabetic rats by inhibiting over-expression of connective tissue growth factor. Chin Med J (Engl). 2011 Jan;124(1):89-94. PMID: 21362314.

Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74. PMID: 21250597.

Neuvonen PJ, Backman JT, Niemi M. Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin. Clin Pharmacokinet. 2008;47(7):463-74. PMID: 18563955.

Bader T, Fazili J, Madhoun M, et al. Fluvastatin inhibits hepatitis C replication in humans. Am J Gastroenterol. 2008 Jun;103(6):1383-9. PMID: 18410471.

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