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Forchlorfenuron is a synthetic cytokinin that inhibits septins and exhibits anti-parasitic, anticancer, and anti-angiogenic activities. Forchlorfenuron induces polymerization of filaments, causing paralysis in Schistosoma. This compound also inhibits proliferation and migration of prostate cancer cells by inducing degradation of HIF-1α in a proteasome-dependent manner. Forchlorfenuron is commonly used as a plant growth regulator.
| Cas No. | 68157-60-8 |
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| Purity | ≥98% |
| Formula | C12H10ClN3O |
| Formula Wt. | 247.68 |
| Chemical Name | N-(2-chloro-4-pyridinyl)-N'-phenyl-Urea |
| IUPAC Name | 1-(2-chloropyridin-4-yl)-3-phenylurea |
| Synonym | KT-30 |
| Melting Point | 165-170°C |
| Solubility | Soluble in water (39 mg/L) at pH 6.4, ethanol (35 mg/mL), DMSO (100 mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zeraik AE, Galkin VE, Rinaldi G, et al. Reversible paralysis of Schistosoma mansoni by forchlorfenuron, a phenylurea cytokinin that affects septins. Int J Parasitol. 2014 Apr 21. [Epub ahead of print]. PMID: 24768753.
Vardi-Oknin D, Golan M, Mabjeesh NJ. Forchlorfenuron disrupts SEPT9_i1 filaments and inhibits HIF-1. PLoS One. 2013 Aug 19;8(8):e73179. PMID: 23977378.
Hu Q, Nelson WJ, Spiliotis ET. Forchlorfenuron alters mammalian septin assembly, organization, and dynamics. J Biol Chem. 2008 Oct 24;283(43):29563-71. PMID: 18713753.