Indolicidin

Product ID I5215

Cas No. 140896-21-5

Purity ≥95%

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Description
Product Info
Shipping and Storage
Downloads
References

Description
Product Info
Shipping and Storage
Downloads
References
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Description

Indolicidin is an antimicrobial peptide (AMP) that interacts with and disrupts membranes. Indolicidin binds negatively charged lipid membranes and induces release of vesicle contents but does not form pores like other AMPs. Indolicidin exhibits antibacterial, hemolytic, and anti-inflammatory activities. This peptide displays antibiotic activity against both gram positive and gram negative bacteria, inhibiting growth of Acinetobacter, Staphyloccocus, and Nocardia, among others. Additionally, indolicidin inhibits production of NO and iNOS in LPS-stimulated macrophages and inhibits production of TNF-α in various other cell lines.

Product Info

Cas No.	140896-21-5
Purity	≥95%
Formula	C₁₀₀H₁₃₂N₂₆O₁₃
Formula Wt.	1906.33
Solubility	Soluble in water (1 mg/mL), DMSO.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	I5215 MSDS PDF
Info Sheet	I5215 Info Sheet PDF

References

Vila-Farres X, Garcia de la Maria C, López-Rojas R, et al. In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2012 Apr;18(4):383-7. PMID: 21672084.

Végh AG, Nagy K, Bálint Z, et al. Effect of antimicrobial peptide-amide: indolicidin on biological membranes. J Biomed Biotechnol. 2011;2011:670589. PMID: 21765635.

Rieg S, Kaasch AJ, Wehrle J, et al. Susceptibility of clinical Staphylococcus aureus isolates to innate defense antimicrobial peptides. Microbes Infect. 2011 Aug;13(8-9):761-5. PMID: 21473929.

Rokitskaya TI, Kolodkin NI, Kotova EA, et al. Indolicidin action on membrane permeability: carrier mechanism versus pore formation. Biochim Biophys Acta. 2011 Jan;1808(1):91-7. PMID: 20851098.

Rieg S, Meier B, Fähnrich E, et al. Differential activity of innate defense antimicrobial peptides against Nocardia species. BMC Microbiol. 2010 Feb 23;10:61. PMID: 20178618.

Nan YH, Park KH, Park Y, et al. Investigating the effects of positive charge and hydrophobicity on the cell selectivity, mechanism of action and anti-inflammatory activity of a Trp-rich antimicrobial peptide indolicidin. FEMS Microbiol Lett. 2009 Mar;292(1):134-40. PMID: 19191872.

Bowdish DM, Davidson DJ, Scott MG, et al. Immunomodulatory activities of small host defense peptides. Antimicrob Agents Chemother. 2005 May;49(5):1727-32. PMID: 15855488.