LKT Labs

Biochemicals for Life Science Research

Foscarnet Sodium

Product ID F5873
Cas No. 63585-09-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $97.50 In stock
5 g $379.80 In stock
10 g $651.10 In stock
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Description

Foscarnet is an antiviral compound that inhibits reverse transcriptase of HIV-1 and DNA polymerase of other viruses, including CMV and HSV. Inhibition of these enzymes prevents DNA synthesis and viral replication. Foscarnet chelates with metal ions and also mimics the pyrophosphate leaving group in DNA polymerase, inducing a closed/un-translocated conformational state. Additionally, foscarnet inhibits type II inorganic phosphate (Pi) transporters in smooth muscle cells, inhibiting Ca2+ deposition and vascular calcification.

Product Info

Cas No.

63585-09-1
Purity

≥98%
Formula

CNa3O5P
Formula Wt.

191.95
IUPAC Name

trisodium;phosphonatoformate
Synonym

Phosphonoformic acid sodium salt, Trisodium phosphonoformate, Foscavir
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

F5873 MSDS PDF
Info Sheet

F5873 Info Sheet PDF

References

Zahn KE, Tchesnokov EP, Götte M, et al. Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J Biol Chem. 2011 Jul 15;286(28):25246-55. PMID: 21566148.

Villa-Bellosta R, Sorribas V. Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate deposition. Arterioscler Thromb Vasc Biol. 2009 May;29(5):761-6. PMID: 19213941.

Marchand B, Tchesnokov EP, Götte M. The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation. J Biol Chem. 2007 Feb 2;282(5):3337-46. PMID: 17145704.

Morfin F, Thouvenot D. Herpes simplex virus resistance to antiviral drugs. J Clin Virol. 2003 Jan;26(1):29-37. PMID: 12589832.

Hardy WD. Foscarnet treatment of acyclovir-resistant herpes simplex virus infection in patients with acquired immunodeficiency syndrome: preliminary results of a controlled, randomized, regimen-comparative trial. Am J Med. 1992 Feb 14;92(2A):30S-35S. PMID: 1531285.

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