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Fosfomycin Calcium

Fosfomycin Calcium

Product ID F5874
Cas No. 26016-98-8
Purity ≥95%
Product Unit SizeCostQuantityStock
250 mg $52.50 In stock
1 g $67.80 In stock
5 g $141.00 In stock
25 g $563.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fosfomycin is an antibiotic initially produced by Streptomyces that exhibits antibacterial, anti-parasitic, antimalarial, and nephroprotective activities. Fosfomycin is active against both gram positive and gram negative bacteria and acts by inhibiting MurA and preventing synthesis of bacterial cell walls. Fosfomycin also inhibits isopentenyl phosphate kinase, an enzyme in the archaeal mevalonate pathway. In vivo, fosfomycin inhibits iron release from the mitochondria, inhibiting lipid peroxidation and preventing aminoglycoside antibiotic-induced nephrotoxicity. This compound also displays some anti-inflammatory benefit, decreasing serum levels of TNF-α, IL-1β, and IL-6 in animal models of septic Pseudomonas infection, increasing survival rates.

Product Info

Cas No.

26016-98-8

Purity

≥95%

Formula

C3H5CaO4P

Formula Wt.

176.12

IUPAC Name

calcium;(3-methyloxiran-2-yl)-dioxido-oxo-λ5-phosphane

Synonym

MK-0955 calcium

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F5874 MSDS PDF

Info Sheet

F5874 Info Sheet PDF

References

Olesen SH, Ingles DJ, Yang Y, et al. Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin. J Basic Microbiol. 2013 May 20. [Epub ahead of print]. PMID: 23686727.

Mabanglo MF, Serohijos AW, Poulter CD. The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase. Biochemistry. 2012 Jan 31;51(4):917-25. PMID: 22148590.

Yanagida C, Ito K, Komiya I, et al. Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue. Chem Biol Interact. 2004 Jul 20;148(3):139-47. PMID: 15276870.

Borrmann S, Adegnika AA, Matsiegui PB, et al. Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children. J Infect Dis. 2004 Mar 1;189(5):901-8. PMID: 14976608.

Matsumoto T, Tateda K, Miyazaki S, et al. Immunomodulating effect of fosfomycin on gut-derived sepsis caused by Pseudomonas aeruginosa in mice. Antimicrob Agents Chemother. 1997 Feb;41(2):308-13. PMID: 9021184.

Custom Order

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