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Gastrin-releasing peptide (BB2) is an endogenous bombesin-like peptide that stimulates the release of gastrin by binding BB2 receptors; it is involved in feeding behavior (acting as an anorexigenic), circadian rhythms, and stress signaling. BB2 induces scratching behavior in vivo and exhibits pro-angiogenic activity in cancer models, inducing expression of IL-8 in a hepatocyte growth factor-dependent manner in gastric cancer cells.
| Cas No. | 93755-85-2 |
|---|---|
| Purity | ≥95% |
| Formula | C130H204N38O31S2 |
| Formula Wt. | 2859.40 |
| Synonym | GRP |
| Solubility | Soluble in water (1 mg/mL), DMSO. |
| Appearance | White to off-white Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Kallingal GJ, Mintz EM. Site-specific effects of gastrin-releasing peptide in the suprachiasmatic nucleus. Eur J Neurosci. 2014 Feb;39(4):630-9. PMID: 24528136.
Lee KH, Koh SA, Kim JR. Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells. Oncol Res. 2013;20(9):393-402. PMID: 23924923.
Sukhtankar DD, Ko MC. Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. PLoS One. 2013 Jun 24;8(6):e67422. PMID: 23826298.
Merali Z, McIntosh J, Anisman H. Role of bombesin-related peptides in the control of food intake. Neuropeptides. 1999 Oct;33(5):376-86. PMID: 10657515.