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Gemfibrozil is a fibrate that exhibits anti-hyperlipidemic and antibacterial activities. Gemfibrozil activates PPARα, increasing synthesis of lipoprotein lipase, which results in decreases in serum total cholesterol, VLDL, LDL, and triglyceride levels and increases in serum HDL levels and ApoA expression. In vitro, gemfibrozil also inhibits enoyl-CoA reductase, preventing fatty acid synthesis and suppressing growth in species of Legionella and Mycobacterium.
| Cas No. | 25812-30-0 |
|---|---|
| Purity | ≥98% |
| Formula | C15H22O3 |
| Formula Wt. | 250.33 |
| Chemical Name | 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid |
| IUPAC Name | 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid |
| Synonym | Decrelip, Genlip, Lipozid, Lipur, Lopid |
| Melting Point | 61-63°C |
| Solubility | Soluble in water and acid (0.0019%). Soluble in dilute base (>1%). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Reich-Slotky R, Kabbash CA, Della-Latta P, et al. Gemfibrozil inhibits Legionella pneumophila and Mycobacterium tuberculosis enoyl coenzyme A reductases and blocks intracellular growth of these bacteria in macrophages. J Bacteriol. 2009 Aug;191(16):5262-71. PMID: 19429621.
Sirtori CR, Franceschini G, Gianfranceschi G, et al. Activity profile of gemfibrozil on the major plasma lipoprotein parameters. Eur J Epidemiol. 1992 May;8 Suppl 1:120-4. PMID: 1505648.