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Notoginsenoside R1

Product ID N5778
Cas No. 80418-24-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $189.00 In stock
10 mg $314.60 In stock
25 mg $629.30 In stock
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  • Description
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Description

Notoginsenoside R1 is a triterpene saponin originally found in species of Panax (ginseng) that exhibits neuroprotective, anti-atherosclerotic, anti-inflammatory, anti-hyperlipidemic, and immunostimulatory activities. Notoginsenoside R1 decreases amyloid-β-induced oxidative damage and MAPK signaling, improving cell viability in cellular models of Alzheimer’s disease. In ApoE knockout animals, notoginsenoside R1 increases expression of glutathione and superoxide dismutase and decreases expression of inflammatory cytokines; it also decreases LDL, triglyceride, and cholesterol levels and increases HDL levels, preventing atherosclerotic lesions. This compound also increases antigen-induced spleenocyte proliferation and IgG titers in vivo.

Product Info

Cas No.

80418-24-2

Purity

≥98%

Formula

C47H80O18

Formula Wt.

933.13

IUPAC Name

(2S,3R,4S,5S,6R)-2-[(2S)-2-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

Solubility

Soluble in DMSO.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

N5778 MSDS PDF

Info Sheet

N5778 Info Sheet PDF

References

Ma B, Meng X, Wang J, et al. Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation. Int Immunopharmacol. 2014 Jun 24;22(1):151-159. PMID: 24975829.

Jia C, Xiong M, Wang P, et al. Notoginsenoside R1 Attenuates Atherosclerotic Lesions in ApoE Deficient Mouse Model. PLoS One. 2014 Jun 16;9(6):e99849. PMID: 24933211.

Sun HX, Chen Y, Ye Y. Ginsenoside Re and notoginsenoside R1: Immunologic adjuvants with low haemolytic effect. Chem Biodivers. 2006 Jul;3(7):718-26. PMID: 17193304.

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