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Ghrelin, human

Ghrelin, human

Product ID G2868
Cas No. 258279-04-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $367.50 In stock
5 mg $824.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ghrelin is an endogenous peptide hormone that regulates feeding behavior, energy homeostasis, and secretion of growth hormone, growth hormone-releasing factor (GHRF/GHRH), and somatostatin. Ghrelin counteracts the effects of leptin, exhibiting orexigenic activity and increasing feeding behavior such as food intake and body weight. Ghrelin activates eNOS in endothelial cells, stimulating activation of AMPK and Akt. Ghrelin also enhances stress-induced fear responding in vivo and increases long-term potentiation (LTP) and dendritic spine synapse formation; it also exhibits cognition enhancing activity, improving spatial learning and memory in other in vivo models.

Product Info

Cas No.

258279-04-8

Purity

≥98%

Formula

C149H249N47O42

Formula Wt.

3370.9

Synonym

Lenomorelin

Solubility

Soluble in 1% acetic acid (1mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G2868 MSDS PDF

Info Sheet

G2868 Info Sheet PDF

References

Meyer RM, Burgos-Robles A, Liu E, et al. A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear. Mol Psychiatry. 2013 Oct 15. [Epub ahead of print]. PMID: 24126924.

Xu X, Jhun BS, Ha CH, Jin ZG. Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation. Endocrinology. 2008 Aug;149(8):4183-92. PMID: 18450953.

Diano S, Farr SA, Benoit SC, et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci. 2006 Mar;9(3):381-8. PMID: 16491079.

Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000 Oct 19;407(6806):908-13. PMID: 11057670.

Custom Order

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