[Gln4]-Neurotensin

Name: [Gln4]-Neurotensin
SKU: N1990
Availability: BackOrder

Product ID N1990

Cas No. 61445-54-3

Purity ≥95%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Neurotensin is a tridecapeptide that exhibits antinociceptive, pro-inflammatory, and gastrointestinal motility modulating activities. Neurotensin induces contractions in smooth muscle cells, playing a role in regulating digestive activity in vitro and in vivo. Additionally, neurotensin induces intracellular Ca2+ release, activating nonselective cation channels and altering pacemaker currents involved in gastrointestinal and colonic motility. In animal models, neurotensin displays sympatho-inhibitory activity, decreases blood pressure and heart rate. Neurotensin exerts its actions through activation of neurotensin receptors; activation of these receptors also stimulates orexin neurons, suggesting a role for neurotensin in mediation of reward, feeding, and wakefulness.

Product Info

Cas No.	61445-54-3
Purity	≥95%
Formula	C₇₈H₁₂₂N₂₂O₁₉
Formula Wt.	1671.9
IUPAC Name	2-[[2-[[2-[[1-[2-[[2-[[1-[6-amino-2-[[4-amino-2-[[5-amino-2-[[3-(4-hydroxyphenyl)-2-[[4-methyl-2-[(5-oxopyrrolidine-2-carbonyl)amino]pentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	N1990 MSDS PDF
Info Sheet	N1990 Info Sheet PDF

References

Kleczkowska P, Lipkowski AW. Neurotensin and neurotensin receptors: characteristic, structure-activity relationship and pain modulation--a review. Eur J Pharmacol. 2013 Sep 15;716(1-3):54-60. PMID: 23500196.

Degolier TF, Brown DR, Duke GE, et al. Neurotensin and cholecystokinin contract gallbladder circular muscle in chickens. Poult Sci. 2013 Aug;92(8):2156-62. PMID: 23873564.

Furutani N, Hondo M, Kageyama H, et al. Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. PLoS One. 2013 Apr 19;8(4):e62391. PMID: 23620827.

Lee J, Kim YD, Park CG, et al. Neurotensin modulates pacemaker activity in interstitial cells of Cajal from the mouse small intestine. Mol Cells. 2012 May;33(5):509-16. PMID: 22441675.

Zogovic B, Pilowsky PM. Intrathecal neurotensin is hypotensive, sympathoinhibitory and enhances the baroreflex in anaesthetized rat. Br J Pharmacol. 2012 May;166(1):378-89. PMID: 22035146.

Law IK, Murphy JE, Bakirtzi K, et al. Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1. J Biol Chem. 2012 Apr 27;287(18):15066-75. PMID: 22416137.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

[Gln4]-Neurotensin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Doripenem Hydrate

7-epi-Taxol

Florfenicol

13-TES-Baccatin III

ABT-199

Marbofloxacin

Puerarin

Loperamide Hydrochloride

Flubendazole

Mechlorethamine Hydrochloride

PF-06447475

ELR-510444

MGCD-0103

H89

Secnidazole

Isopropyl Thiogalactoside

Zerumbone

Telbivudine

Clemizole Hydrochloride

Gastrin-1, rat

Footer