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GLYX-13 Trifluoroacetate

GLYX-13 Trifluoroacetate

Product ID G4797
Cas No. 117928-94-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $93.80 In stock
5 mg $228.80 In stock
25 mg $481.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GLYX-13 is a peptide with the sequence T-P-P-T that exhibits antidepressant and neuromodulatory activities; it acts as a partial agonist at NMDA receptors. GLYX-13 reverses PCP- and ketamine-induced memory deficits and increases sensitivity to long-term potentiation (LTP). GLYX-13 also decreases depressive symptoms in vivo without psychomimetic or dissociative effects.

Product Info

Cas No.

117928-94-6

Purity

≥98%

Formula

C18H31N5O6

Formula Wt.

413.48

Chemical Name

L-Threonyl-L-prolyl-L-prolyl-L-threoninamide

IUPAC Name

L-Threonyl-L-prolyl-L-prolyl-L-threoninamide

Synonym

Rapastinel, GLYX-13, TPPT

Solubility

Soluble in water (2 mg/mL), DMSO (30 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G4797 MSDS PDF

Info Sheet

G4797 Info Sheet PDF

References

Rajagopal L, Burgdorf JS, Moskal JR, et al. GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice. Behav Brain Res. 2015 Nov 26. [Epub ahead of print]. PMID: 26632337.

Burgdorf J, Zhang XL, Weiss C, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11. PMID: 26343295.

Burgdorf J, Kroes RA, Zhang XL, et al. Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats. Behav Brain Res. 2015 Nov 1;294:177-85. PMID: 26210936.

Newport DJ, Carpenter LL, McDonald WM, et al. Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression. Am J Psychiatry. 2015 Oct 1;172(10):950-66. PMID: 26423481.

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