Description
GW-5074 is an indole that functions as a highly selective Raf-1 (c-Raf) kinase inhibitor and is used to study Ras/Raf-1/ERK signaling. This compound inhibits desuccinylation activity of Sirt5 (a histone deacetylase), altering DNA repair and metabolism in vitro. GW-5074 is also neuroprotective against 6-OHDA toxicity, which is a commonly studied experimental model of Parkinson’s Disease.