• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
GW-5074

GW-5074

Product ID G8850
Cas No. 220904-83-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $214.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GW-5074 is an indole that functions as a highly selective Raf-1 (c-Raf) kinase inhibitor and is used to study Ras/Raf-1/ERK signaling. This compound inhibits desuccinylation activity of Sirt5 (a histone deacetylase), altering DNA repair and metabolism in vitro. GW-5074 is also neuroprotective against 6-OHDA toxicity, which is a commonly studied experimental model of Parkinson’s Disease.

Product Info

Cas No.

220904-83-6

Purity

≥98%

Formula

C15H8Br2INO2

Formula Wt.

520.94

Chemical Name

2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-

IUPAC Name

(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one

Solubility

DMSO 104 mg/mL (199.63 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G8850 MSDS PDF

Info Sheet

G8850 Info Sheet PDF

References

Suenkel B, Fischer F, Steegborn C. Inhibition of the human deacylase Sirtuin 5 by the indole GW5074. Bioorg Med Chem Lett. 2013 Jan 1;23(1):143-6. PMID: 23195732.

Li J, Fan Y, Zhang YN, et al. The Raf-1 inhibitor GW5074 and the ERK1/2 pathway inhibitor U0126 ameliorate PC12 cells apoptosis induced by 6-hydroxydopamine. Pharmazie. 2012 Aug;67(8):718-24. PMID: 22957439.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A480010

    AM630

    CB2 receptor antagonist.

    ≥97%
  • R0348

    Ramelteon

    Melatonin analog; MT1/2 agonist.

    ≥99%
  • S8243

    Sulbactam Sodium

    β-lactamase inhibitor.

    ≥98%
  • A464766

    Altenuene

    Alternaria mycotoxin which may be found in food...

    ≥98%
  • P1845

    Pelitinib

    EGFR inhibitor.

    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • T0092

    1-Hydroxybaccatin I

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • A7578

    Astragaloside IV

    Found in Astragalus membranaceus.

    ≥98%
  • D1746

    Deltarasin Hydrochloride Trihydrate

    PDEδ inhibitor.

    ≥99%
  • N5210

    Nociceptin

    Endogenous neuropeptide, involved in opioid sig...

    ≥98%
  • S760004

    Stachybotrylactam

    Spirodihydrobenzofuranlactam

    ≥98%
  • C0262

    L-Carnitine

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • P8169

    Purpurin

    Anthraquinone pigment found in madder root; O-a...

    ≥90%
  • T5944

    Tolmetin Sodium

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • K0034

    Kahweol Eicosanate

    Diterpene found in coffee beans.

    ≥98%
  • O7053

    L-Ornithine Hydrochloride

    Non-proteinogenic amino acid, L-arginine metabo...

    ≥98%
  • C2802

    CH5132799

    p110α PI3K inhibitor.

    ≥98%
  • O446185

    Oleuropein

    Bioactive compound from olive tree.

    ≥98%
  • C0169

    Carbenoxolone Disodium

    Synthetic derivative of glycyrrhizin; connexin ...

    ≥97%
  • A5070

    Angiotensin Acetate

    Peptide, derivative of AT I, cleavage product o...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only