LKT Labs

Biochemicals for Life Science Research

GW-788388

GW-788388

Product ID G8800
Cas No. 452342-67-5
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $143.70 In stock
25 mg $447.40 In stock
Bulk Quote

Quicklinks

Description

GW-788388 inhibits activin receptor-like kinase 5 (ALK5), suppressing TGF-β activity; it exhibits anti-fibrotic and cardioprotective activities. GW-788388 increases survival in studies of Trypanosoma infection and prevents Chagas disease-induced development of cardiac fibrosis. This compound also attenuates systolic dysfunction and left ventricular remodeling in animal models of myocardial infarction. In animal models of diabetes, GW-788388 decreases the occurrence of renal fibrosis.

Product Info

Cas No.

452342-67-5
Purity

≥97%
Formula

C25H23N5O2
Formula Wt.

425.49
IUPAC Name

4-{4-[5-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl}-N-(tetrahydro-2H-pyran-4-yl)benzamide
Synonym

GW788388, GW 788388
Solubility

DMSO Solubility: 15 mg/mL (35.25 mM)

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

G8800 MSDS PDF
Info Sheet

G8800 Info Sheet PDF

References

de Oliveira FL, Araújo-Jorge TC, de Souza EM, et al. Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl Trop Dis. 2012;6(6):e1696. PMID: 22720109.

Tan SM, Zhang Y, Connelly KA, et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1415-25. PMID: 20154262.

Petersen M, Thorikay M, Deckers M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008 Mar;73(6):705-15. PMID: 18075500.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L960006

    LY-2606368

    CHK1 inhibitor.

    ≥98%
  • B1545

    Benzalkonium Bromide

    Quaternary ammonium cationic surfactant, dissoc...

    ≥95%
  • I058584

    Ibotenic Acid

    Analog of glutamate

    ≥98%
  • R0161

    Rapamycin

    Macrolide originally produced by Streptomyces; ...

    ≥99%
  • M0113

    Madecassoside

    Triterpenoid found in Centella.

    ≥90%
  • P2815

    Phenylbutyrate Sodium

    HDAC inhibitor.

    ≥98%
  • E7377

    Estriol

    Endogenous steroid hormone, estradiol metabolit...

    ≥97%
  • P3542

    PIK-93

    p110α and p110γ PI3K inhibitor.

    ≥98%
  • P698579

    Propantheline Bromide

    Antimuscarinic

    ≥98%
  • A4847

    Amylin, human

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • S6800

    SR1001

    RORα/γ inverse agonist.

    ≥99%
  • B3210

    R-Bicalutamide

    AR antagonist.

    ≥98%
  • A0968

    Adrenocorticotropic Hormone (1-24), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • L3374

    Lisinopril Dihydrate

    Enalapril analog; ACE inhibitor.

    ≥98%
  • O4917

    Omeprazole

    H+/K+ ATPase inhibitor.

    ≥98%
  • A9814

    AZD-4547

    FGFR inhibitor.

    ≥98%
  • A6826

    L-Arginine Hydrochloride

    Endogenous amino acid, also found in meat, dair...

    ≥98%
  • H174466

    Helvolic acid

    A fungal metabolite that inhibits protein synth...

    ≥98%
  • P0219

    Paeonol

    Found in Paeonia, Arisaema, Dioscorea; MAO-A/B ...

    ≥98%
  • C1600

    Carcinoembryonic Antigen (605-613)

    Carcinoembryonic antigen epitope.

    ≥95%