• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
GW-788388

GW-788388

Product ID G8800
Cas No. 452342-67-5
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $143.70 In stock
25 mg $447.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GW-788388 inhibits activin receptor-like kinase 5 (ALK5), suppressing TGF-β activity; it exhibits anti-fibrotic and cardioprotective activities. GW-788388 increases survival in studies of Trypanosoma infection and prevents Chagas disease-induced development of cardiac fibrosis. This compound also attenuates systolic dysfunction and left ventricular remodeling in animal models of myocardial infarction. In animal models of diabetes, GW-788388 decreases the occurrence of renal fibrosis.

 

Product Info

Cas No.

452342-67-5

Purity

≥97%

Formula

C25H23N5O2

Formula Wt.

425.49

IUPAC Name

4-{4-[5-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl}-N-(tetrahydro-2H-pyran-4-yl)benzamide

Synonym

GW788388, GW 788388

Solubility

DMSO Solubility: 15 mg/mL (35.25 mM)

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G8800 MSDS PDF

Info Sheet

G8800 Info Sheet PDF

References

de Oliveira FL, Araújo-Jorge TC, de Souza EM, et al. Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl Trop Dis. 2012;6(6):e1696. PMID: 22720109.

Tan SM, Zhang Y, Connelly KA, et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1415-25. PMID: 20154262.

Petersen M, Thorikay M, Deckers M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008 Mar;73(6):705-15. PMID: 18075500.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1020

    n-Butyl Analog of Paclitaxel

    Fermentation impurity

    ≥95%
  • O9201

    Oxaliplatin

    Pt-based DNA cross-linker.

    ≥98%
  • G4799

    Glycitin

    Glycosylated isoflavone found in soy; TAS2R ago...

    ≥98%
  • P698574

    Prolylrapamycin

    Rapamycin analog

  • P7033

    Primaquine Phosphate

    Alters membrane permeability, prevents transport v...
    ≥98% (titration)
  • P0344

    Palbociclib Isethionate

    CDK4/6 inhibitor.

    ≥98%
  • C5647

    Colistin Sulfate

    Polymixin, antimicrobial peptide, induces forma...

    Biological Potency: ≥19366 IU/mg
  • C0174

    Carmofur

    Pyrimidine analog, fluorouracil derivative; thy...

    ≥97%
  • C7098

    Crystalline peptide

    Dipeptide.

    ≥95%
  • O4104

    Okadaic Acid Sodium

    Shellfish toxin produced by dinoflagellates and se...
    ≥98%
  • A4443

    L-(+)-Alliin

    Optically active cysteine derivative found in A...

    ≥98%
  • B5000

    BMS-911543

    JAK2 inhibitor.

    ≥99%
  • D1994

    Dexrazoxane

    Iron chelator.

    ≥98%
  • P200637

    PF-04745637

    TRPA1 antagonist

    ≥98%
  • C3251

    Cinnarizine

    FIASMA, L-type Ca2+ channel blocker, D2 antagon...

    ≥98%
  • E2002

    Efaroxan Hydrochloride

    α2-adrenergic and imidazoline-1 antagonist, AT...

    ≥99%
  • P6958

    Protopanaxatriol

    Triterpene sapogenin found in species of Panax;...

    ≥95%
  • H3278

    HIV Reverse Transcriptase A2.1 Peptide

    Peptide, HIV-1 RT A2.1 epitope.

    ≥95%
  • C1630

    Cefoperazone Sodium

    β-lactam cephalosporin; penicillin binding pro...

    ≥98%
  • C5654

    Concanavalin A

    Lectin found in Canavelia, plant mitogen that bind...

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only