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Helodormin is a E7Q, E8Q analog of helodermin. Helodermin is a peptide originally found in Heloderma lizards. Helodermin exhibits vasodilatory and antihypertensive activities, decreasing blood pressure in vivo; this arterial relaxation is accompanied by a decrease in intracellular Ca2+ and an increase in cAMP. Helodermin may also exhibit anticancer benefit, inhibiting cell proliferation of small cell lung cancer (SCLC) cells in vitro.
| Cas No. | 89468-62-2 |
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| Purity | ≥98% |
| Formula | C176H285N47O49 |
| Formula Wt. | 3843.47 |
| Chemical Name | 5-L-isoleucine-8-L-glutamine-9-L-glutamine- 24-L-alanine-30-L-arginine-34-de-L-arginine-36-L- prolinamide-37-de-L-serine-38-de-L-serine- Helospectin I |
| Synonym | Exendin 2, Helodermin, Heliodermin. |
| Solubility | Soluble in water, acetic acid, TFA. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Uddman R, Goadsby PJ, Jansen-Olesen I, et al. Helospectin-like peptides: immunochemical localization and effects on isolated cerebral arteries and on local cerebral blood flow in the cat. J Cereb Blood Flow Metab. 1999 Jan;19(1):61-7. PMID: 9886356.
Tanaka Y, Horikawa N, Ishiro H, et al. Glibenclamide-sensitive mechanism is involved in helodermin-produced vasodilatation in rat mesenteric artery. Res Commun Mol Pathol Pharmacol. 1997 Nov;98(2):141-56. PMID: 9467823.
Maruno K, Said SI. Small-cell lung carcinoma: inhibition of proliferation by vasoactive intestinal peptide and helodermin and enhancement of inhibition by anti-bombesin antibody. Life Sci. 1993;52(24):PL267-71. PMID: 8389407.
Grundemar L, Högestätt ED. Vascular effects of helodermin, helospectin I and helospectin II: a comparison with vasoactive intestinal peptide (VIP). Br J Pharmacol. 1990 Mar;99(3):526-8. PMID: 2331581.