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HPGDS Inhibitor 1 is an inhibitor of hematopoietic prostaglandin D synthase (HPGDS) that decreases release of PGD2. HPGDS Inhibitor 1 displays anti-inflammatory, anti-allergic, and immunomodulatory activities, decreasing antigen-induced immune and inflammation responses in animal models.
| Cas No. | 1033836-12-2 |
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| Purity | ≥98% |
| Formula | C19H19F4N3O |
| Formula Wt. | 381.37 |
| IUPAC Name | 6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]nicotinamide |
| Synonym | Prostaglandin D Synthase (hematopoietic-type) Inhibitor I, H-PGDS Inhibitor I, MDK36122 |
| Solubility | 10 mM in DMSO |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Carron CP, Trujillo JI, Olson KL, et al. Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Med Chem Lett. 2010 Feb 2;1(2):59-63. PMID: 24900177.