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HT-2 toxin is a trichothecene mycotoxin initially produced by Fusarium and is also a metabolite of T2 toxin. HT-2 toxin is often produced in grains used as livestock feed and in the production of products for human consumption such as cereal. HT-2 toxin passes across the blood-brain barrier more easily than T2 toxin, exhibiting neurotoxicity by inducing apoptosis.
| Cas No. | 26934-87-2 |
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| Purity | ≥98%, TLC, HPLC |
| Formula | C22H32O8 |
| Formula Wt. | 424.48 |
| Chemical Name | [(1S,2R,4S,7R,9R,10R,11S,12S)-2-(acetyloxymethyl)-10,11-dihydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-4-yl] 3-methylbutanoate |
| IUPAC Name | [(1S,2R,4S,7R,9R,10R,11S,12S)-2-(acetyloxymethyl)-10,11-dihydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-4-yl] 3-methylbutanoate |
| Synonym | NSC278571, Mycotoxin HT 2 |
| Melting Point | 151-152°C |
| Solubility | Soluble in Ethanol, DMSO. Very slightly soluble in water. |
| Appearance | Colorless Film |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ortiz J, Van Camp J, Mestdagh F, et al. Mycotoxin co-occurrence in rice, oat flakes and wheat noodles used as staple foods in Ecuador. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013 Dec 7. [Epub ahead of print]. PMID: 24313870.
Weidner M, Hüwel S, Ebert F, et al. Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. PLoS One. 2013;8(3):e60484. PMID: 23544145.
Zhang Y, Liu H, Lin X, et al. Dysregulation of cells cycle and apoptosis in human induced pluripotent stem cells chondrocytes through p53 pathway by HT-2 toxin: an in vitro study. Frontiers in Gen. 2021 Aug 4;12:677723. PMID: 34421989.