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Hypocrellin A exhibits antibacterial and immunomodulatory activities. In vitro, hypocrellin A inhibits MHC II antigen presentation but not MHC I antigen presentation. Additionally, this compound increases levels of ROS and induces cell wall damage in Staphylococcus, Salmonella, Escherichia, and Bacillus.
Contains ~16 % hypocrellin B
| Cas No. | 77029-83-5 |
|---|---|
| Purity | ≥77%, contains ~16% B |
| Formula | C30H26O10 |
| Formula Wt. | 546.52 |
| IUPAC Name | 12-acetyl-9,13,17-trihydroxy-5,10,16,21-tetramethoxy-13-methylhexacyclo[13.8.0.02,11.03,8.04,22.018,23]tricosa-1(15),2(11),3(8),4(22),5,9,16,18(23),20-nonaene-7,19-dione |
| Synonym | Hypocrellin |
| Solubility | Soluble in heptane, DMSO. |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Du W, Sun C, Liang Z, et al. Antibacterial activity of hypocrellin A against Staphylococcus aureus. World J Microbiol Biotechnol. 2012 Nov;28(11):3151-7. PMID: 22864599.
Park S, Im SA, Kim KH, et al. Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing. Immune Netw. 2011 Dec;11(6):412-5. PMID: 22346783.
Su Y, Sun J, Rao S, et al. Photodynamic antimicrobial activity of hypocrellin A. J Photochem Photobiol B. 2011 Apr 4;103(1):29-34. PMID: 21300554.
Xu Y, Zhang Z, Zhang H. Raman spectroscopic study of DNA after photosensitive damage caused by hypocrellins A and B. Sci China C Life Sci. 1998 Aug;41(4):360-6. PMID: 18726251.