LKT Labs

Biochemicals for Life Science Research

SR1001

SR1001

Product ID S6800
Cas No. 1335106-03-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $61.80 In stock
5 mg $92.70 In stock
25 mg $259.60 In stock
100 mg $525.00 In stock
Bulk Quote

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Description

SR1001 is an inverse agonist at RORα/γ receptors that prevents Th17 cell development, differentiation, and function. It exhibits anti-diabetic, anti-inflammatory, immunomodulatory, and antidepressant activities. In animal models of diabetes, SR1001 decreases diabetes incidence and insulitis, suppresses expression of pro-inflammatory cytokines, and increases levels of CD4+, Foxp3+ Treg cells. In animal models of depression-like behaviors, SR1001 decreases Th17-dependent learned helplessness.

Product Info

Cas No.

1335106-03-0
Purity

≥99%
Formula

C15H13F6N3O4S2
Formula Wt.

477.40
IUPAC Name

N-(5-{[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]sulfamoyl}-4-methyl-1,3-thiazol-2-yl)acetamide
Solubility

DMSO: ≥ 39 mg/mL
Appearance

Tan powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S6800 MSDS PDF
Info Sheet

S6800 Info Sheet PDF

References

Solt LA, Banerjee S, Campbell S, et al. ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes. Endocrinology. 2015 Mar;156(3):869-81. PMID: 25560829.

Beurel E, Harrington LE, Jope RS. Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol Psychiatry. 2013 Apr 1;73(7):622-30. PMID: 23174342.

Solt LA, Kumar N, Nuhant P, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011 Apr 28;472(7344):491-4. PMID: 21499262.

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