• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Iberin

Iberin

Product ID I0416
Cas No. 505-44-2
Purity ≥97%
Product Unit SizeCostQuantityStock
10 mg $228.30 In stock
25 mg $537.70 In stock
50 mg $857.20 In stock
100 mg $1,505.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Iberin is an isothiocyanate (ITC) and sulforaphane homolog that exhibits antioxidative and anticancer chemotherapeutic activity. Like other ITCs, iberin may display chemopreventive potential by inducing phase II enzymes. In vitro, iberin induces Nrf2 nuclear translocation and increases levels of heme oxygenase-1 and glutamylcysteine synthetase, both potentially related to alterations in ERK signaling. Iberin also increases expression of antioxidative enzymes thioredoxin reductase 1 and glutathione peroxidase 2 in cellular models. In cancer cells, iberin induces p21 expression, decreases expression of cyclin-dependent kinases (CDKs) 2, 4, and 6, and increases caspase activity, resulting in apoptosis.

Product Info

Cas No.

505-44-2

Purity

≥97%

Formula

C5H9NOS2

Formula Wt.

163.26

Chemical Name

1-Isothiocyanato-3-(methylsufinyl) propane

IUPAC Name

1-isothiocyanato-3-methylsulfinylpropane

Synonym

3-Methylsulfinylpropyl isothiocyanate, 3-(Methylsulfinyl)-propyl isothiocyanate

Solubility

Ethanol. DMSO to 11 mg/mL. DMF to 16 mg/mL.

Appearance

Slight yellowish liquid

Shipping and Storage

Store Temp

-80°C

Ship Temp

Ambient

Downloads

MSDS

I0416 MSDS PDF

Info Sheet

I0416 Info Sheet PDF

References

Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058.

Barrera LN, Cassidy A, Wang W, et al. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochim Biophys Acta. 2012 Oct;1823(10):1914-24. PMID: 22820176.

Traka MH, Chambers KF, Lund EK, et al. Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). Nutr Cancer. 2009;61(1):137-45. PMID: 19116884.

Jadhav U, Ezhilarasan R, Vaughn SF, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. Int J Mol Med. 2007 Mar;19(3):353-61. PMID: 17273780.

Jakobsen TH, Bragason SK, Phipps RK, et al. Food as a source for quorum sensing inhibitors: iberin frmo horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-2421. PMID: 22286987.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O4104

    Okadaic Acid Sodium

    Shellfish toxin produced by dinoflagellates and se...
    ≥98%
  • G4518

    Glucaric Acid Calcium Tetrahydrate

    Oxidized non-cylic hexose sugar.

    ≥98%
  • A488246

    AMG-232

    MDM2-p53 inhibitor

    ≥99%
  • T162051

    Tebipenem

    Broad-spectrum antibiotic

    ≥99%
  • E6134

    Epimedin C

    Flavonoid found in Epimedium sagittatum.

    ≥98%
  • N3225

    Nigericin Sodium

    Polyether cationic ionophore.

    ≥98%
  • L1881

    Leuprolide Acetate

    GnRH analog; GnRH1 agonist.

    ≥95%
  • P7219

    Pseudolaric Acid B

    Diterpene acid found in Pseudolarix kaempferi.<...

    ≥98%
  • F8147

    Fulvestrant

    Induces ER degradation.

    ≥98%
  • A5059

    Amoxapine

    5-HT2/3/6/7, D2/3/4, histamine H1, α1-adrenerg...

    ≥98%
  • B6801

    Brassinin

    Phytoalexin, indole found in cruciferous vegeta...

    ≥98%
  • D3214

    2′,3′-Dideoxyinosine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • T1754

    Tenatoprazole

    H+/K+ ATPase inhibitor.

    ≥98%
  • A5132

    Amikacin Disulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • C0366

    Carvedilol Phosphate Hemihydrate

    FIASMA; α1- and β1/2-adrenergic antagonist.

    ≥98%
  • L1852

    Lenalidomide

    Thalidomide derivative; cereblon and TNF-α inh...

    ≥98%
  • H0003

    H89

    PKA inhibitor, potential ROCK, S6K1, MSK1, PKB ...

    ≥98%
  • T1672

    Terbinafine Hydrochloride

    Allylamine; squalene oxidase and KSR1 inhibitor...

    ≥98%
  • G1855

    Gentiopicroside

    Secoiridoid glycoside found in Gentiana and Cep...

    ≥95%
  • C3208

    Ciclopirox Olamine

    Hydroxypyridone, metal ion chelator; mTOR inhib...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only