• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Ibudilast

Ibudilast

Product ID I0480
Cas No. 50847-11-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $183.10 In stock
25 mg $422.50 In stock
100 mg $1,408.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ibudilast is an inhibitor of phosphodiesterases 3 and 5 (PDE3/5) that also inhibits the leukotriene D4 (LTD4) receptor in airway smooth muscle cells. Ibudilast exhibits vasodilatory, anti-inflammatory, anti-asthma, anti-platelet, analgesic, and antinociceptive activities. In clinical settings, ibudilast increases cerebral blood flow in several brain regions after ischemic stroke. Ibudilast also non-competitively inhibits the functions of pro-inflammatory macrophage migration inhibitory factor (MIF), preventing glial cell activation. In other cellular models, ibudilast decreases activation of NF-κB, inhibiting HIV-1 Tat-induced production of TNF-α.

Product Info

Cas No.

50847-11-5

Purity

≥98%

Formula

C14H18N2O

Formula Wt.

230.31

IUPAC Name

2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one

Synonym

3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine, KC-404, AV-411

Melting Point

53-54°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I0480 MSDS PDF

Info Sheet

I0480 Info Sheet PDF

References

Inoue N, Fukuda S, Inada T, et al. Effect of ibudilast on the reciprocal inhibitory visual-vestibular interaction closely related to dizziness after cerebral ischemia. J Stroke Cerebrovasc Dis. 2014 Jan;23(1):51-5. PMID: 23085301.

Kiebala M, Maggirwar SB. Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PLoS One. 2011 Apr 8;6(4):e18633. PMID: 21494611.

Cho Y, Crichlow GV, Vermeire JJ, et al. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11313-8. PMID: 20534506.

Ledeboer A, Hutchinson MR, Watkins LR, et al. Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opin Investig Drugs. 2007 Jul;16(7):935-50. PMID: 17594181.

Kishi Y, Ohta S, Kasuya N, et al. Ibudilast modulates platelet-endothelium interaction mainly through cyclic GMP-dependent mechanism. J Cardiovasc Pharmacol. 2000 Jul;36(1):65-70. PMID: 10892662.

Ohashi M, Kanai R, Nishino K, et al. Antagonistic effect of KC-404, a new anti-asthmatic agent, on leukotriene D4-induced contractile responses in isolated guinea pig smooth muscles. Prostaglandins. 1986 Dec;32(6):875-88. PMID: 3562868.

Ohashi M, Ohkubo H, Kito J, et al. A new vasodilator 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (KC-404) has a dual mechanism of action on platelet aggregation. Arch Int Pharmacodyn Ther. 1986 Oct;283(2):321-34. PMID: 3024600.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L283720

    Losartan Carboxylic acid

    Active metabolite of losartan

    ≥ 99%
  • A5326

    Aniracetam

    AMPA positive allosteric modulator, D2, 5-HT2A,...

    ≥98%
  • C1644

    Celecoxib

    NSAID; COX-2 inhibitor.

    ≥99%
  • E537331

    Enniatin Complex

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • O4102

    Okadaic Acid Ammonium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • B5648

    Bombesin

    GRP analog, found in Bombina; bombesin and GRP ...

    ≥95%
  • C9773

    L-Cystine

    Endogenous amino acid, forms disulfide bridges ...

    ≥98%
  • C0173

    Carmustine

    Nitrosourea, DNA alkylator.

    ≥98%
  • X1753

    Xenopsin

    Peptide hormone, neurotensin analog found in am...

    ≥95%
  • D3201

    Diallyl Sulfide

    Organosulfur found in garlic.

    ≥98%
  • D5994

    Doxepin Hydrochloride

    FIASMA, 5-HT1/2, M1-5 mAChR, α1-adrenergic, hi...

    ≥98%
  • V1600

    VE-821

    ATR inhibitor.

    ≥98%
  • C2957

    Cholesterol

    Endogenous sterol component of animal cell memb...

    ≥97%
  • G0245

    Gallocatechin Gallate

    Polyphenol found in Camilla sinensis; HIV integ...

    ≥98%
  • A4931

    3-Aminobenzamide

    PARP inhibitor.

    ≥97%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • S0225

    SAG Dihydrochloride

    Smoothened agonist.

    ≥98%
  • V0148

    Valproic Acid

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • R1777

    9-cis-Retinoic Acid

    Vitamin A derivative; RAR and RXR agonist.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only