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Ifosfamide is a nitrogen mustard alkylator that exhibits anticancer chemotherapeutic activity. Ifosfamide is clinically used to treat various cancers. Because ifosfamide is very cytotoxic, it is often co-administered with cytoprotective agents such as MESNA.
| Cas No. | 3778-73-2 |
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| Purity | ≥98% |
| Formula | C7H15Cl2N2O2P |
| Formula Wt. | 261.09 |
| Chemical Name | N, 3-Bis(2-chloroethyl)-tetrahydro-2H-1,3,2-oxaza- phosphorin-2-amine 2-oxide |
| IUPAC Name | N,3-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine |
| Synonym | Holoxan, Ifex, Ifomide, Isoendoxan, Isophosphamide, Mitoxana |
| Melting Point | 39-41°C, 51.0°C |
| Solubility | 100mg/mL in water. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Vincenzi B, Frezza AM, Santini D, et al. New therapies in soft tissue sarcoma. Expert Opin Emerg Drugs. 2010 Jun;15(2):237-48. PMID: 20465449.
Nissim I, Horyn O, Daikhin Y, et al. Ifosfamide-induced nephrotoxicity: mechanism and prevention. Cancer Res. 2006 Aug 1;66(15):7824-31. PMID: 16885387.