LKT Labs

Biochemicals for Life Science Research

Indomethacin

Product ID I5315
Cas No. 53-86-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $42.70 In stock
10 g $78.50 In stock
25 g $139.90 In stock
100 g $312.20 In stock
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Description

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antipyretic, tocolytic, and anti-metastatic activities. Indomethacin is a non-selective COX-1 and COX-2 inhibitor that is clinically used to treat headaches; like other NSAIDs, indomethacin may induce intestinal damage or gastric lesions. Indomethacin delays premature labor in clinical settings by decreasing uterine contractility. In vitro, indomethacin decreases cancer cell migration by suppressing Ca2+ influx.

Product Info

Cas No.

53-86-1
Purity

≥98%
Formula

C19H16ClNO4
Formula Wt.

357.79
Chemical Name

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole- 3-acetic acid
IUPAC Name

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Synonym

Amuno, Idomethine.
Melting Point

158-162°C
Solubility

Insoluble in water. Soluble in ethanol (20 mg/mL), or acetone.
Appearance

White/Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I5315 MSDS PDF
Info Sheet

I5315 Info Sheet PDF

References

Adewoye EO, Salami AT. Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats. Niger J Physiol Sci. 2013 Dec 20;28(2):193-9. PMID: 24937396.

Guo YC, Chang CM, Hsu WL, et al. Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization. Molecules. 2013 Jun 4;18(6):6584-96. PMID: 23736792.

Summ O, Evers S. Mechanism of action of indomethacin in indomethacin-responsive headaches. Curr Pain Headache Rep. 2013 Apr;17(4):327. PMID: 23423598.

Giles W, Bisits A. Preterm labour. The present and future of tocolysis. Best Pract Res Clin Obstet Gynaecol. 2007 Oct;21(5):857-68. PMID: 17459777.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

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