• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
JW55

JW55

Product ID J8800
Cas No. 664993-53-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $126.50 In stock
25 mg $548.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

JW55 is an inhibitor of tankyrases (TNKS1/2) that stabilizes the β-catenin degradation complex, suppressing Wnt signaling. JW55 displays anti-obesity and potential anticancer activities. In animal models of high-fat diet and diabetes, JW55 decreases body weight and intestinal epithelial stem cell proliferation.

Product Info

Cas No.

664993-53-7

Purity

≥98%

Formula

C25H26N2O5

Formula Wt.

434.49

IUPAC Name

N-[4-({[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}carbamoyl)phenyl]-2-furamide

Synonym

Tankyrase 1/2 Inhibitor IV

Solubility

10 mM in DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

J8800 MSDS PDF

Info Sheet

J8800 Info Sheet PDF

References

Mao J, Hu X, Xiao Y, et al. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46. PMID: 23884889.

Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 Jun 1;72(11):2822-32. PMID: 22440753.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P6956

    Prostaglandin E1

    Endogenous prostaglandin, vasodilator.

    ≥98%
  • S5749

    Somatostatin-14

    Endogenous neuropeptide hormone; somatostatin a...

    ≥95%
  • A7656

    Atomoxetine Hydrochloride

    NET and SERT inhibitor, NMDA antagonist.

    ≥99%
  • O2146

    R-(+)-Ofloxacin

    Fluoroquinolone, optically active isomer of ofl...

    ≥98%
  • A985130

    AZD-7762

    CHK1 inhibitor.

    ≥98%
  • S5869

    Sorafenib Tosylate

    c-Raf, RET, VEGFR1 inhibitor, potential HMT inh...

    ≥99%
  • E7376

    Estradiol

    Endogenous steroid hormone, involved in regulat...

    ≥97%
  • D0255

    Dantrolene Sodium Heptahydrate

    Hydantoin derivative; RyR antagonist, L-type Ca...

    ≥98%
  • F1895

    Fexofenadine Hydrochloride

    Histamine H1 antagonist.

    ≥98%
  • C0275

    Castanospermine

    O-GlcNAcase inhibitor.

    ≥98%
  • M3196

    MHY-1485

    mTOR activator.

    ≥98%
  • C2800

    Chalcone

    Enone.

    ≥97%
  • A4002

    AK-7

    SIRT2 inhibitor.

    ≥98%
  • C0048

    Cambinol

    SIRT inhibitor.

    ≥98%
  • B1979

    Betulinic Acid

    Pentacyclic triterpene.

    ≥99%
  • D0033

    Daidzin

    Isoflavone, phytoestrogen, found in soy.

    ≥98%
  • C9608

    Cycloastragenol

    Triterpene aglycone found in Radix Astragali; t...

    ≥98%
  • E5369

    Enrofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • S7618

    StemRegenin 1 Hydrochloride

    AhR antagonist.

    ≥98%
  • V7200

    VS-5584

    PI3K inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only