| Product Unit Size | Cost | Quantity | Stock |
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JW55 is an inhibitor of tankyrases (TNKS1/2) that stabilizes the β-catenin degradation complex, suppressing Wnt signaling. JW55 displays anti-obesity and potential anticancer activities. In animal models of high-fat diet and diabetes, JW55 decreases body weight and intestinal epithelial stem cell proliferation.
| Cas No. | 664993-53-7 |
|---|---|
| Purity | ≥98% |
| Formula | C25H26N2O5 |
| Formula Wt. | 434.49 |
| IUPAC Name | N-[4-({[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}carbamoyl)phenyl]-2-furamide |
| Synonym | Tankyrase 1/2 Inhibitor IV |
| Solubility | 10 mM in DMSO |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Mao J, Hu X, Xiao Y, et al. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46. PMID: 23884889.
Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 Jun 1;72(11):2822-32. PMID: 22440753.