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Kb NB 142-70

Kb NB 142-70

Product ID K0652
Cas No. 1233533-04-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $165.50 In stock
25 mg $590.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Kb NB 142-70 is an inhibitor of PKD that is used to study PKD activity in research models. Kb NB 142-70 prevents angiotensin II-induced phosphorylation of histone deacetylases and increases activation of Akt in intestinal epithelial cells. This compound may also inhibit migration of intestinal epithelial cells.

Product Info

Cas No.

1233533-04-4

Purity

≥98%

Formula

C11H9NO2S2

Formula Wt.

251.32

Chemical Name

9-Hydroxy-3,4-dihydro-2H-[1]benzothiolo[2,3-f][1,4]thiazepin-5-one

IUPAC Name

9-Hydroxy-3,4-dihydro[1]benzothieno[2,3-f][1,4]thiazepin-5(2H)-one

Synonym

Kb-NB142-70; 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one; CHEMBL1672571

Solubility

DMSO 100mM

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

K0652 MSDS PDF

Info Sheet

K0652 Info Sheet PDF

References

Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541.

Ni Y, Sinnett-Smith J, Young SH, et al. PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One. 2013 Sep 9;8(9):e73149. Erratum in: PLoS One. 2014;9(1). PMID: 24039875.

Young SH, Rozengurt N, Sinnett-Smith J, et al. Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G356-66. PMID: 22595992.

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