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Kendomycin

Kendomycin

Product ID K1653
Cas No. 183202-73-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $162.30 Please Inquire
500 µg $324.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Kendomycin is a cytotoxic macrolide antibiotic that exhibits antibacterial and anticancer activities. Kendomycin induces depolarization of the mitochondrial membrane potential and activates caspase 3, inducing apoptosis in lymphoma cells. Kendomycin inhibits the proteasome and also binds Bcl-xl. Kendomycin is also an antagonist at endothelin receptors.

Product Info

Cas No.

183202-73-5

Purity

≥98%

Formula

C29H42O6

Formula Wt.

486.64

IUPAC Name

(1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one

Synonym

(−)-TAN 2162

Solubility

Soluble in DMSO or methanol.

Appearance

Yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

K1653 MSDS PDF

Info Sheet

K1653 Info Sheet PDF

References

Janssen CO, Lim S, Lo EP, et al. Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5771-3. PMID: 18845435.

Elnakady YA, Rohde M, Sasse F, et al. Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin. Chembiochem. 2007 Jul 23;8(11):1261-72. PMID: 17592829.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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