Description
KSQ-4279 is an inhibitor of the deubiquitinating enzyme USP1.
KSQ-4279
Product ID K740640
Cas No. 2446480-97-1
Purity ≥98%
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Product Info
| Cas No. | 2446480-97-1 |
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| Purity | ≥98% |
| Formula | C27H25F3N8O |
| Formula Wt. | 534.55 |
| IUPAC Name | 6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine |
| Synonym | USP1-IN-1; KSQ4279 |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Cadzow L, Brenneman J, Sullivan P, et al. Development of KSQ-4279 as a first-in-class USP1 inhibitor for the treatment of BRCA-deficient cancers. Eur J Cancer. 2020 Oct 1;138(Supplement 2,S52).
Cadzow L, Tobin E, Sullivan P, et al. Abstract ND01: KSQ-4279: A first-in-class USP1 inhibitor for the treatment of cancers with homologous recombination deficiencies. Cancer Res. 2022;82(12_Supplement):ND01.