LKT Labs

Biochemicals for Life Science Research

LBH-589

LBH-589

Product ID L0528
Cas No. 404950-80-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $73.50 In stock
25 mg $157.50 In stock
50 mg $231.00 In stock
Bulk Quote

Quicklinks

Description

LBH-589 (Panobinostat) is a hydroxamic acid inhibitor of class I (1, 2, 3, and 11) histone deacetylases (HDACs) that is clinically used to treat multiple myeloma and is currently in clinical trials as a potential treatment for other cancers. This compound displays anticancer chemotherapeutic and anti-metastatic activities. LBH-589 reverses the epithelial-to-mesenchymal transition (EMT), inhibits cell proliferation, invasion, and migration, and decreases tumor growth in animal models of breast cancer. In hepatocellular carcinoma cells, LBH-589 inhibits oncogenic miRNA expression and upregulates expression of APAF1 and Beclin-1.

Product Info

Cas No.

404950-80-7
Purity

≥98%
Formula

C21H23N3O2
Formula Wt.

349.43
IUPAC Name

(2E)-N-Hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide
Synonym

LBH589, Panobinostat
Solubility

DMSO 69 mg/mL (197.46 mM) Water Insoluble Ethanol Insoluble
Appearance

Off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

L0528 MSDS PDF
Info Sheet

L0528 Info Sheet PDF

References

Andreu-Vieyra CV, Berenson JR. The potential of panobinostat as a treatment option in patients with relapsed and refractory multiple myeloma. Ther Adv Hematol. 2014 Dec;5(6):197-210. PMID: 25469210.

Rhodes LV, Tate CR, Segar HC, et al. Suppression of triple-negative breast cancer metastasis by pan-DAC inhibitor panobinostat via inhibition of ZEB family of EMT master regulators. Breast Cancer Res Treat. 2014 Jun;145(3):593-604. PMID: 24810497.

Henrici A, Montalbano R, Neureiter D, et al. The pan-deacetylase inhibitor panobinostat suppresses the expression of oncogenic miRNAs in hepatocellular carcinoma cell lines. Mol Carcinog. 2013 Dec 23. [Epub ahead of print]. PMID: 24375802.

Ovejero-Sanchez M, Gonzalez-Sarmiento R, Herrero AB. Synergistic effect of chloriquine and panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair. Neoplasia. 2021 May;23(5):515-528. PMID: 339930758.

Wilson A, Gupta V, Liu Q, et al. Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer. Neoplasia. 2022 Feb;24(2):63-75. PMID: 34933276.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C2818

    Chelerythrine Chloride

    benzophenanthridine alkaloid found in Chelidoni...

    ≥98%
  • F3207

    Fibronectin CS-1 Peptide

    Peptide; α4β1 integrin activator.

    ≥95%
  • E4902

    Emamectin B1 Benzoate

    Semi-synthetic avermectin; GABA potentiator.

    ≥80%
  • C9677

    Cyclocytidine Hydrochloride

    Pyrimidine nucleoside analog; DNA synthesis inh...

    ≥98%
  • S761025

    Stauprimide

    Analog of staurosporine.

    ≥98%
  • T5605

    Tobramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • C0271

    Carfilzomib

    Epoxomicin analog; proteasome inhibitor.

    ≥98%
  • C0171

    Carboplatin

    Pt-based DNA cross-linker.

    ≥99%
  • R3477

    Ritodrine Hydrochloride

    Phenylethylamine; β2-adrenergic agonist, SK/BK...

    ≥98%
  • X1753

    Xenopsin

    Peptide hormone, neurotensin analog found in am...

    ≥95%
  • A9814

    AZD-4547

    FGFR inhibitor.

    ≥98%
  • C0261

    Captopril

    ACE inhibitor.

    ≥98%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • B8248

    Bumetanide

    Loop diuretic; NKCC symporter and KCC2 co-trans...

    ≥98%
  • V344761

    Vitamin K2

    2-methyl-1,4-naphthoquinone derivative

    ≥98%
  • C0243

    Calcitonin Gene Related Peptide (8-37), human

    Calcitonin-family peptide frgament, involved in...

    ≥95%
  • S3353

    Sinomenine Hydrochloride

    Alkaloid found in Sinomenium; acid-sensing ion ...

    ≥98%
  • T8269

    (S)-ar-Turmerone

    Sesquiterpene found in Curcuma.

    ≥97%
  • M4102

    MK-1775

    Wee1 inhibitor.

    ≥98%
  • P0109

    P7C3A20

    Fluorinated aminopropyl carbazole, neuroprotect...

    ≥94%